en Reumatology Reumatology Editorial Editorial <span style="font-size:10.0pt"><span new="" roman="" style="font-family:" times="">Chronic systemic inflammation represents a unifying mechanism linking many of today&#39;s most prevalent chronic diseases. Although considerable progress has been made in elucidating its molecular pathways, important questions remain regarding optimal biomarkers, individualized risk assessment, and targeted therapeutic interventions. Future research should focus on identifying clinically applicable inflammatory biomarkers, validating anti-inflammatory treatment strategies, and determining whether reducing chronic inflammatory burden translates into meaningful improvements in morbidity, functional capacity, quality of life, and survival. Recognition, early identification, and effective management of chronic systemic inflammation may ultimately become central components of precision medicine and preventive healthcare</span></span> Chronic, inflammation, diseases 476 479 http://caspjim.com/browse.php?a_code=A-10-1-24&slc_lang=en&sid=1 Behzad Heidari heidaribeh@yahoo.com 100319475328460057749 100319475328460057749 Yes Babol University of Medical Sciences, Babol, Iran Reza Ghadimi rezaghadimi@yahoo.com 100319475328460057750 100319475328460057750 No Social Determinants of Health Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran