:: Volume 9, Issue 2 (1-2018) ::
Caspian J Intern Med 2018, 9(2): 140-143 Back to browse issues page
Is 99m Tc-methylene diphosphonate bone scintigraphy a sensitive method for detecting bone lesions in multiple myeloma?
Mohsen Vakili-sadeghi , Sadegh Sedaghat
Babol university of medical sciences2. Cancer Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran , mvakili89@gmail.com
Abstract:   (1535 Views)
Background: Bone lesion in multiple myeloma (MM) is most commonly presented as a lytic lesion in this disease. Determination of extent of bone lesions in MM is necessary to follow-up the patients. Whole body bone scan with 99m, Tc-methylene diphosphonate (MDP) has a lower sensitivity than other modalities.
Methods: From the patients with MM admitted to Ayatollah Rouhani Hospital of Babol-Iran from 2009 to 2015, who had undergone whole body bone scan during diagnostic process, were entered into the study. Findings of bone scan were compared with MRI.
Results: Of the 19 patients, sixteen (84.2%) of them had positive finding in bone scan, fifteen (78.9%) had MRI of the spine. While of the thirteen patients who had positive finding in MRI, seven (53.8%) had more positive finding in thorcolumbosacral MRI than in bone scan.
Conclusions: 99m-Tc MDP bone scan is a sensitive but insufficient method for detecting bone lesions in MM.

Keywords: Tc-99m methylene diphosphonate, bone lesion, multiple myeloma
Full-Text [PDF 185 kb]   (200 Downloads)    
Type of Study: Original Article | Subject: Hematology
Received: 2017/04/6 | Accepted: 2017/07/18 | Published: 2018/01/8

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Volume 9, Issue 2 (1-2018) Back to browse issues page