[صفحه اصلی ]   [Archive]  
:: صفحه اصلي :: درباره نشريه :: آخرين شماره :: تمام شماره‌ها :: جستجو :: ثبت نام :: ارسال مقاله :: تماس با ما ::
:: دوره 10، شماره 1 - ( 10-1397 ) ::
جلد 10 شماره 1 صفحات 92-97 برگشت به فهرست نسخه ها
Serum YKL-40 levels and disease characteristics in patients with rheumatoid arthritis
چکیده:   (260 مشاهده)
Background: The present study aimed to evaluate serum YKL-40 levels in patients with rheumatoid arthritis (RA) compared to healthy subjects and to search whether there is an association between YKL-40 levels and disease characteristics in RA.
Methods: In this cross-sectional study, 60 RA patients based on the ACR/EULAR 2010 criteria and 30 age- and sex-matched healthy controls were included. In patients, clinical examination was performed and disease activity score 28 (DAS-28) measure of disease activity was assessed. Serum YKL-40 level was measured using ELISA kit.
Results: The mean±SD age of patients and controls was 54.86±11.65 and 50.71±3.72 years, respectively). Serum YKL-40 level was significantly higher in RA patients (951.63±639.98 pg/mL) compared to healthy controls (444.92±150.37 pg/mL) (P<0.001). There was no significant difference in serum YKL-40 level according to the activity of disease (p>0.05). There were significant positive correlations between serum YKL-40 level with disease activity (r=0.347, P=0.007) and rheumatoid factor (r=0.396, P=0.002). There were no significant correlations between serum YKL-40 level with demographic characteristics as well as biochemical measurements including serum creatinine, blood urea nitrogen, erythrocyte sedimentation rate, C-reactive protein and anti-cyclic citrullinated peptide.
Conclusion: Our study revealed higher serum YKL-40 levels in RA patients compared to healthy controls, which correlated positively with disease activity. Therefore, YKL-40 can be considered as a novel biomarker for disease activity estimation in RA.
متن کامل [PDF 436 kb]   (23 دریافت)    
نوع مطالعه: Original Article | موضوع مقاله: Reumatology
دریافت: ۱۳۹۷/۳/۱۹ | پذیرش: ۱۳۹۷/۵/۱۳ | انتشار: ۱۳۹۷/۸/۶
ارسال نظر درباره این مقاله
نام کاربری یا پست الکترونیک شما:

CAPTCHA code



XML   English Abstract   Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Jafari-Nakhjavani M R, Ghorbanihaghjo A, Bagherzadeh-Nobari B, Malek-Mahdavi A, Rashtchizadeh N. Serum YKL-40 levels and disease characteristics in patients with rheumatoid arthritis . Caspian J Intern Med. 2019; 10 (1) :92-97
URL: http://caspjim.com/article-1-1510-fa.html

Serum YKL-40 levels and disease characteristics in patients with rheumatoid arthritis . 1. 1397; 10 (1) :92-97

URL: http://caspjim.com/article-1-1510-fa.html



دوره 10، شماره 1 - ( 10-1397 ) برگشت به فهرست نسخه ها
Caspian Journal of Internal Medicine
Persian site map - English site map - Created in 0.06 seconds with 31 queries by YEKTAWEB 3816