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:: دوره 10، شماره 4 - ( 6-1398 ) ::
جلد 10 شماره 4 صفحات 359-369 برگشت به فهرست نسخه ها
Calcium and vitamin D supplementation effects on metabolic factors, menstrual cycles and follicular responses in women with polycystic ovary syndrome: A systematic review and meta-analysis
چکیده:   (387 مشاهده)
Background: Polycystic ovary syndrome (PCOS) is the most popular endocrine disorder in reproductive age with unknown etiology and many comorbidities. This systematic review focused on the effectiveness of calcium and vitamin D (Ca/ Vit.D) supplementation on metabolic factors, menstrual cycles, and follicular responses in PCOS patients.
Methods: Relevant studies were identified from the following electronic databases including Pub Med, Web of Science, Cochrane Central Register of Controlled Trials (CENTRAL), The Cochrane Library, issue Oct. 2018, Evidence Based Medicine Reviews (EBMR), Google Scholar, EMBASE, as well as Farsi databases including Magiran and SID from 2000 to 2018. Out of 449 articles, six clinical trials met the inclusion criteria.
Results: Out of six studies included in the study, only three studies had sufficient data for meta-analysis. Overall, studies showed that prescribing Ca/ Vit. D supplementation with metformin improved menstrual regularity and follicular maturation and significant decreases in serum insulin levels, homeostasis model of assessment-insulin resistance (HOMA-IR) and fasting blood sugar (FBS) and also significant rises on quantitative insulin sensitivity check index (QUICKI) at two studies. Hirsutism and level of testosterone decreased significantly after adding Ca/ Vit. D to metformin in two different studies. Based on two different trials, co-supplementation of Ca/ Vit. D had a significant impact to decrease serum triglycerides and VLDL-cholesterol levels as well as levels of cholesterol and LDL.
Conclusion: It is possible that calcium and vitamin D supplementation improve menstrual disturbances and metabolic factors in PCOS in a long-term period, but further trials are still needed to confirm these findings.
متن کامل [PDF 636 kb]   (62 دریافت)    
نوع مطالعه: Review Article | موضوع مقاله: Health
دریافت: ۱۳۹۷/۱۱/۱۵ | پذیرش: ۱۳۹۸/۲/۷ | انتشار: ۱۳۹۸/۷/۳
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Shojaeian Z, Sadeghi R, Latifnejadroudsary R. Calcium and vitamin D supplementation effects on metabolic factors, menstrual cycles and follicular responses in women with polycystic ovary syndrome: A systematic review and meta-analysis. Caspian J Intern Med. 2019; 10 (4) :359-369
URL: http://caspjim.com/article-1-1753-fa.html

Calcium and vitamin D supplementation effects on metabolic factors, menstrual cycles and follicular responses in women with polycystic ovary syndrome: A systematic review and meta-analysis. 1. 1398; 10 (4) :359-369

URL: http://caspjim.com/article-1-1753-fa.html



دوره 10، شماره 4 - ( 6-1398 ) برگشت به فهرست نسخه ها
Caspian Journal of Internal Medicine
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