Cutaneous amyloidosis as the first presentation of Waldenstrom macroglobulinemia
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Rana Rafiei , Hojat Eftekhari , Behnam Rafiee |
Skin Research Center, Dermatology Department, Guilan University of Medical Sciences, Rasht, Iran , rafieirana2@gmail.com |
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Abstract: (3219 Views) |
Background: Waldenstrom macroglobulinemia is a lymphoplasmacytic lymphoma with elevated serum immunoglobulin M and multi-organ involvement. Primary systemic amyloidosis usually develops due to immunoglobulin light chains depositions in different organs due to an underlying gammopathy.
Case presentation: Our patient was an 86-year-old man with macroglossia, ecchymotic patches and bullous lesions associated with a skin laxity on the periorbital, palmar, and glans penis areas. Skin biopsy confirmed dermal amyloid depositions. In serum immunofixation electrophoresis, prominent monoclonal immunoglobulin-M lambda light chains were detected associated with prominent lymphoplasmacytic infiltration in bone marrow biopsy which was diagnosed as Waldenstrom macroglobulinemia.
Conclusion: Skin involvement presenting as cutaneous amyloidosis could be the first manifestation of Waldenstrom macroglobulinemia. We should think about an underlying gammopathy in an old patient with skin laxity and ecchymosis. |
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Keywords: Primary systemic amyloidosis, Waldenstrom macroglobulinemia |
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Full-Text [PDF 271 kb]
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Type of Study: case report |
Subject:
Dermathology Received: 2019/03/24 | Accepted: 2019/07/10 | Published: 2020/05/21
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