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:: دوره 11، شماره 3 - ( 2-1399 ) ::
جلد 11 شماره 3 صفحات 12-0 برگشت به فهرست نسخه ها
The assessment of function, histopathological changes, and oxidative stress in liver tissue due to ionizing and non-ionizing radiations
چکیده:   (186 مشاهده)
Background: Compared to past decades, humans are exposed to rapidly increasing levels of radiofrequency electromagnetic radiations (RF-EMF). Despite numerous studies, the biological effects of human exposure to different levels of RF-EMF are not fully understood, yet. This study aimed to evaluate the bioeffects of exposure to "900/1800 MHz" and “2.4 GHz" RF-EMFs, and x-rays as well as their potential for inducing simple additive, adaptive, or synergistic effects.
Methods: 120 Wistar rats were randomly divided into ten groups of 12 each. The rats were exposed to either sham, EMF, 10 cGy, and 8 Gy x-rays or a combination of these exposures. The levels of liver enzymes in serum samples by an auto-analyzer. Moreover, the histopathological changes and the levels of Malondialdehyde, Nitric oxide, ferric reducing antioxidant power, total thiols, and protein carbonyl assays were measured.
Results: Among the markers of liver function, GGT was not associated with irradiation but, AST, ALT, and ALP showed some levels of association. Lipid peroxidation and protein carbonyl assays after 8 Gy irradiation were increased, but pre-exposure to RF-EMF could modulate their changes. At the cellular level, the frequency of lobular inflammation was associated with our intervention types.
Conclusions: the exposure to both ionizing and non-ionizing radiations could alter some liver function tests. A short term pre-exposure to RF-EMF before exposure to an 8 Gy challenging dose of x-rays caused the alterations in oxidative stress markers and liver function tests, which indicate the possible involvement of oxidative stress in the process of adaptive response.
     
نوع مطالعه: Original Article | موضوع مقاله: Internal
دریافت: 1398/9/11 | پذیرش: 1399/1/19 | انتشار: 1399/3/1
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Borzoueisileh S, Shabestani Monfared A, Ghorbani H, Mortazavi S M J, Shafiee M, Doustimotlagh A H, et al . The assessment of function, histopathological changes, and oxidative stress in liver tissue due to ionizing and non-ionizing radiations. Caspian J Intern Med. 2020; 11 (3) :12-0
URL: http://caspjim.com/article-1-2131-fa.html

The assessment of function, histopathological changes, and oxidative stress in liver tissue due to ionizing and non-ionizing radiations. 1. 1399; 11 (3) :12-0

URL: http://caspjim.com/article-1-2131-fa.html



دوره 11، شماره 3 - ( 2-1399 ) برگشت به فهرست نسخه ها
Caspian Journal of Internal Medicine
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