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The effect of narrowband ultraviolet B phototherapy on serum folate level
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Azar Shirzadian kebria    , Meghdad Hosseini , Sorayya Khafri |
| Department of Dermatology, Yahyanejad Hospital, Babol University of Medical Sciences, Babol, Iran , shirzadiank@gmail.com |
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Abstract: (3601 Views) |
Background: Narrowband ultraviolet B (NB-UVB) phototherapy has been used as a common treatment for dermatologic diseases such as psoriasis and vitiligo and generally considered a safe form of therapy during pregnancy. Invitro photodegradation of folate after exposure to UVB radiation has been documented but studies on UVB-induced alternation of serum folate level have reported inconsistent results. The aim of this study was to investigate the effect of NB-UVB radiation on serum folate level.
Methods: In this study, serum folate levels were evaluated in patients at baseline and after 30 sessions of NB-UVB irradiation.
Results: Twenty patients completed the study: 10 psoriasis, 7 vitiligo and 3 mycosis fungoides (patch stage). Mean serum folate level had significantly decreased from 2.76±0.59 ng/ml at baseline to 1.34±0.15 ng/ml after 30 sessions. (Mean NB-UVB cumulative dose 40.35±16.80 j/cm2, P=0.001).
Conclusion: Serum folate levels may decrease after long-term NB-UVB phototherapy in patients with skin disorders. |
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| Keywords: narrowband ultraviolet B phototherapy, folate, psoriasis, vitiligo |
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Full-Text [PDF 139 kb]
(718 Downloads)
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Type of Study: Original Article |
Subject:
Dermathology
Received: 2020/05/12 | Accepted: 2020/06/20 | Published: 2021/03/30
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