دوره 12، شماره 2 - ( 12-1399 )
جلد 12 شماره 2 صفحات 183-180 |
برگشت به فهرست نسخه ها
چکیده: (3935 مشاهده)
Background: Narrowband ultraviolet B (NB-UVB) phototherapy has been used as a common treatment for dermatologic diseases such as psoriasis and vitiligo and generally considered a safe form of therapy during pregnancy. Invitro photodegradation of folate after exposure to UVB radiation has been documented but studies on UVB-induced alternation of serum folate level have reported inconsistent results. The aim of this study was to investigate the effect of NB-UVB radiation on serum folate level.
Methods: In this study, serum folate levels were evaluated in patients at baseline and after 30 sessions of NB-UVB irradiation.
Results: Twenty patients completed the study: 10 psoriasis, 7 vitiligo and 3 mycosis fungoides (patch stage). Mean serum folate level had significantly decreased from 2.76±0.59 ng/ml at baseline to 1.34±0.15 ng/ml after 30 sessions. (Mean NB-UVB cumulative dose 40.35±16.80 j/cm2, P=0.001).
Conclusion: Serum folate levels may decrease after long-term NB-UVB phototherapy in patients with skin disorders.
Methods: In this study, serum folate levels were evaluated in patients at baseline and after 30 sessions of NB-UVB irradiation.
Results: Twenty patients completed the study: 10 psoriasis, 7 vitiligo and 3 mycosis fungoides (patch stage). Mean serum folate level had significantly decreased from 2.76±0.59 ng/ml at baseline to 1.34±0.15 ng/ml after 30 sessions. (Mean NB-UVB cumulative dose 40.35±16.80 j/cm2, P=0.001).
Conclusion: Serum folate levels may decrease after long-term NB-UVB phototherapy in patients with skin disorders.
نوع مطالعه: Original Article |
موضوع مقاله:
Dermathology
دریافت: 1399/2/23 | پذیرش: 1399/3/31 | انتشار: 1400/1/10
دریافت: 1399/2/23 | پذیرش: 1399/3/31 | انتشار: 1400/1/10
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