:: Volume 13, Issue 1 (Winter 2022) ::
Caspian J Intern Med 2022, 13(1): 70-75 Back to browse issues page
Serum dipeptidyl peptidase-4 activity and progranulin level in polycystic ovary syndrome
Maryam Abolghasemi , Soleiman Mahjoub , Sedighe Esmaeilzadeh
Department of Clinical Biochemistry, School of Medicine, Babol University of Medical Sciences, Babol, Islamic Republic of Iran , smahjoub20@gmail.com
Abstract:   (2491 Views)
Background: Evidence showed that abnormal alteration of adipokines level may perform a key role in polycystic ovary syndrome (PCOS) pathogenesis. Dipeptidyl peptidase-4 (DPP4) and progranulin (PGRN) are two novel adipokines related to insulin resistance (IR). Thus, we aimed to determine the serum DPP4 activity and PGRN level in PCOS patients with and without IR, and non-PCOS women.
Methods: Ninety women were recruited in the present study including 60 PCOS patients (divided into two groups of 30 IR and 30 non-IR) and 30 non-PCOS women. Serum levels of insulin, fasting blood glucose, PGRN, and DPP4 activity were measured, and IR indices were calculated.
Results: DPP4 activity was significantly higher in PCOS-IR and PCOS-NIR patients than non-PCOS women (p<0.001, P=0.011, respectively), whereas no significant variation was detected between two groups of PCOS subjects. There was no significant difference in the level of PGRN in the three groups of the present study.
Conclusion: The present study suggests that increasing DPP4 activity may be associated with PCOS.
Keywords: Polycystic ovary syndrome, Dipeptidyl peptidase-4, Progranulin, Adipokine, Insulin resistance
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Type of Study: Original Article | Subject: Biochimestry
Received: 2020/09/26 | Accepted: 2021/03/8 | Published: 2022/01/30

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Volume 13, Issue 1 (Winter 2022) Back to browse issues page