:: دوره 13، شماره 1 - ( 10-1400 ) ::
جلد 13 شماره 1 صفحات 22-16 برگشت به فهرست نسخه ها
Improvement of cognitive deficit of curcumin on scopolamine-induced Alzheimer’s disease models
چکیده:   (1390 مشاهده)
Background: It has been suggested that curcumin may be useful in diseases with cognitive dysfunction because it slows the progression and leads to the improvement of cognitive functions. In this study, the protective effects of curcumin on scopolamine-induced rat models of cognitive impairment were evaluated.
Methods: 21 male Wistar Albino rats, 1 year old, 200±25 grams, were included in the study. They were divided into three groups (n: 7 in each group); the untreated control group, scopolamine group, and the group treated with curcumin and then exposed to scopolamine. Animals were evaluated for behavioral tasks with the Morris Water Maze test. Interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-alpha), total oxidative status (TOS), and total antioxidative status (TAS) were measured in hippocampal tissues. CRP levels were measured in serum specimens.
Results: We found that the length to reach the platform was the highest in the scopolamine group, and the lowest in the curcumin group (p<0.001). Time to reach the platform was the longest in the scopolamine group, and the shortest in the curcumin group (P=0.002). The length to reach the platform was the highest in the scopolamine group, and the lowest in the control group in the probe test (p<0.001). IL-6 levels were higher in the scopolamine group than the curcumin group (P=0.017) and the control group (P=0.005).
Conclusion: We revealed that curcumin provides a protective effect on scopolamine-induced cognitive impairment mimicking Alzheimer's disease.  The use of curcumin for the protection of cognition in individuals at risk of developing AD may be considered.
متن کامل [PDF 245 kb]   (339 دریافت)    
نوع مطالعه: Original Article | موضوع مقاله: Internal
دریافت: 1399/8/2 | پذیرش: 1399/11/20 | انتشار: 1400/11/10



XML   English Abstract   Print



بازنشر اطلاعات
Creative Commons License این مقاله تحت شرایط Creative Commons Attribution-NonCommercial 4.0 International License قابل بازنشر است.
دوره 13، شماره 1 - ( 10-1400 ) برگشت به فهرست نسخه ها