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:: دوره 13، شماره 4 - ( 7-1401 ) ::
جلد 13 شماره 4 صفحات 826-818 برگشت به فهرست نسخه ها
A pure Cutaneous Rosai-Dorfman disease: case report and a review of the literature
چکیده:   (1293 مشاهده)
Background: Cutaneous Rosai-Dorfman disease (CRDD) is a rare variant of benign histiocytic proliferative disorder limited to the skin. The underlying etiology is still unclear, but it had been claimed that infections, immunodeficiencies, and autoimmune disorders might have a role in the etiology of this disorder. The characteristic presentation of RDD is lymphadenopathy due to abnormal production and accumulation of histiocytes in lymph nodes; however, the extra-nodal areas could also be affected, such as cutaneous. Herein, we presented a 45-year-old Iranian woman presented with an atypical pure cutaneous Rosai Dorfman disease, in addition to a summarized list of atypical cases of RDD that are reported as pure cutaneous RDD with atypical presentation.
Case presentation:  Herein, we presented a 45-year-old woman who referred to us with an ulcerative nodule with a size of 5×5 cm on her buttock, gradually growing over one year. After the primary evaluations, a biopsy specimen was obtained, and histologic studies revealed a dense cellular infiltrate involving the dermis and the subcutis, which was composed of abundant sheets of large histiocytes with admixtures of lymphocytes, plasma cells, neutrophils, and eosinophils within their cytoplasm -known as the emperipolesis phenomenon. The immunohistochemistry staining was positive for S100 and CD68 and negative for CD1a.
Conclusion: The diagnosis of CRDD was confirmed based on these histopathological findings.

 
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نوع مطالعه: Review Article | موضوع مقاله: Dermathology
دریافت: 1400/3/8 | پذیرش: 1400/8/25 | انتشار: 1401/6/11
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Montazer F, Farahani S, Shaka Z, Aryanian Z, Goodarzi A. A pure Cutaneous Rosai-Dorfman disease: case report and a review of the literature. Caspian J Intern Med 2022; 13 (4) :818-826
URL: http://caspjim.com/article-1-2932-fa.html

A pure Cutaneous Rosai-Dorfman disease: case report and a review of the literature. 1 1401; 13 (4) :826-818

URL: http://caspjim.com/article-1-2932-fa.html



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دوره 13، شماره 4 - ( 7-1401 ) برگشت به فهرست نسخه ها
Caspian Journal of Internal Medicine
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