Volume 15, Issue 3 (Summer 2024)
Caspian J Intern Med 2024, 15(3): 370-373 |
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Multiple Sclerosis Research Center, Neuroscience institute, Tehran University of Medical Sciences, Tehran, Iran , abdorrezamoghadasi@gmail.com
Abstract: (2076 Views)
Multiple Sclerosis (MS) pathophysiologically is a dynamic and progressive disease that involves all parts of central nervous system. This widespread involvement of the CNS has paved the way for proposing a new theory in MS in which MS is considered as a connectomopathy. Connectomopathy is a new concept describing the diseases in which not only the brain connectome is completely and extensively damaged, but the defective connectome itself can also become a breeding ground for the disease’s progression. Connectomopathy provides a dynamic picture of MS. Since each person’s connectome is unique to him/herself, so MS patients’ connectomopathy varies from one to another. This variety not only challenges the classification of MS into different phenotypes, but also emphasizes the need for providing a personalized approach for the treatment of these patients.
Policy Brief: Review Article |
Subject:
Neurology
Received: 2022/10/17 | Accepted: 2023/10/22 | Published: 2024/05/1
Received: 2022/10/17 | Accepted: 2023/10/22 | Published: 2024/05/1
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