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Factor V Leiden, MTHFR, and FXIIIVal34Leu gene polymorphisms and their association with clinical features and risk of diabetic retinopathy in patients with type 2 diabetes
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Atefeh Rahimi    , Nastaran Moridi , Amin Golestani , Gholamreza Anani-Sarab , Fatemeh Salmani , Gholamhossein Yaqubi , Behzad Mesbahzadeh , Mohammad Ali Jalalifar , Mohammad Malekaneh , Seyed Mehdi Sajjadi |
| Cellular and molecular research center, Birjand University of medical sciences, Birjand, Iran , mehdi.sadjadi@bums.ac.ir |
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Abstract: (719 Views) |
Background: Diabetic retinopathy (DR) is expanding to epidemic levels globally due to the progressing prevalence of diabetes mellitus (DM). In this study, the association between factor V Leiden (FVL), MTHFRC677T, and FXIIIVal34Leu polymorphisms and diabetic retinopathy was investigated in Eastern Iran.
Methods: This case-control study enlisted the participation of 300 people (diabetic patients=100, diabetic retinopathy patients=100, healthy controls=100), and polymorphisms were examined by Tetra primer ARMS-PCR.
Results: The frequency of FVL (p=0.294) and FXIIIVal34Leu (P=0.349) polymorphism showed no significant results between the genotype frequency in the mentioned groups. In contrast, MTHFRC677T SNP was significantly different in diabetic patients and controls (P=0.008). The MTHFRC677T polymorphism was found to be connected with increased systolic blood pressure in patients who had the TT genotype (130.96±11.92mm/Hg; P=0.011).
Conclusion: Our study recommended that the MTHFRC677T polymorphism may offer to DR development. Studies with larger sample sizes and a wider spectrum of populations are authorized to verify this finding.
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| Keywords: Diabetic retinopathy, Factor V Leiden, MTHFR, Factor XIII, T-ARMS-PCR |
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Full-Text [PDF 620 kb]
(286 Downloads)
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Type of Study: Original Article |
Subject:
Hematology
Received: 2022/11/18 | Accepted: 2023/03/28 | Published: 2024/01/19
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