Biochemical profile of bile fluid in patients with malignant cholestasis in comparison with cholestasis due to biliary stone
|
|
|
|
چکیده: (7606 مشاهده) |
Background: Cholangiocarcinoma is an invasive biliary malignancy
with poor prognosis. Diagnostic accuracy of conventional methods is low which
is mainly due to the specific anatomy of the disease. The aim of this study was
to evaluate the diagnostic value of biochemical profile and tumor marker of the
bile in patients with malignant cholestasis compared to that of choledocholithiasis.
Methods: In this cross-sectional study, 46 patients with
extrahepatic cholestasis were enrolled (20 patients with malignant cholestasis
and 26 patients with choledocolithiasis) A definitive diagnosis of cholangiocarcinoma
was made by imaging, cytology and biopsy. Bile fluid was obtained by aspiration
through endoscopic retrograde cholagiopantreatography (ERCP) catheter or
percutaneous drainage in patients with choledocolithiasis and
cholangiocarcinoma respectively. Sex and age were matched in two groups. Data
regarding the biochemical profile (triglyceride, (TG), cholesterol, billirubin
and HDL) and CA19.9 level of the bile fluid were collected, then using the SPSS
software, the data were analyzed.
Results: Bile fluid level of TG, cholesterol, high – density
lipoprotein (HDL), direct bilirubin and CA19.9 were significantly higher in
patients with benign cholestasis in comparison with malignant cholestasis
(P<0.001, P<0.001, P<0.001, P=0.012 and P= 0.03, respectively).
Conclusion: Our study showed that the CA19.9 level of bile fluid
in extrahepatic cholestasis due to biliary stone was significantly higher than
those with cholangiocarcinoma, as is the biliary level of TG, cholesterol,
high-density lipoprotein (HDL) and direct bilirubin. Thus they may help in the
differentiation of benign versus malignant extra hepatic cholestasis.
|
|
|
|
متن کامل [PDF 125 kb]
(2455 دریافت)
|
نوع مطالعه: Original Article |
موضوع مقاله:
Gastroentrology دریافت: 1394/4/1 | پذیرش: 1394/4/1 | انتشار: 1394/4/1
|
|
|
|
|
ارسال نظر درباره این مقاله |
|
|