[Home ] [Archive]    
:: Main :: About :: Current Issue :: Archive :: Search :: Submit :: Contact ::
:: Volume 8, Number 3 (6-2017) ::
Caspian J Intern Med 2017, 8(3): 172-177 Back to browse issues page
Cancer risk among patients with multiple sclerosis: A cohort study in Isfahan, Iran
Masoud Etemadifar, Hamidreza Jahanbani Ardakani *, Sara Ghaffari, Mahboobeh Fereidan-Esfahani, Hossein Changaei, Nazila Aghadoost, Ameneh Jahanbani-Ardakani, Negin Moradkhani
Students Research Committee, Isfahan University of Medical Sciences, Isfahan, Iran , hamidreza_jahanbaniardakani@yahoo.com
Abstract:   (646 Views)

Background: Multiple sclerosis (MS), a central nervous system (CNS) autoimmune disorder, affects 2.3 million people around the world. Cancer kills around 7.5 million people annually. Both diseases have similar risks and intertwining molecular causes. Most studies focusing on MS and cancer have found an insignificant difference or reduction in the amount of cancer found in the MS community.

Methods: We performed a cohort study using data from Isfahan Multiple Sclerosis Society (IMSS) and Isfahan cancer society and followed-up for 8 years on average (2006-2014). All of the 1718 MS patients were diagnosed according to McDonald’s criteria, then standardized incidence ratio and the numbers of expected cancer case were calculated.

Results: While patients had an insignificant change in cancer prevalence, men had fewer cancer cases and women showed an increased prevalence of cancer. Certain types of cancer proved statistically significant. Breast cancer, nervous system cancers, and lymphoma were elevated in the cohort.

Conclusion: Our results support the hypothesis that MS significantly affects certain cancers in a protective or associative manner. All cancer rates, except breast cancer, cancers located in the nervous system, and lymphomas were reduced in cohort, suggesting that unregulated immune function may provide protective effects to MS patients against cancer.

Keywords: Cancer, Multiple Sclerosis, Cohort, Isfahan, Iran
Full-Text [PDF 356 kb]   (210 Downloads)    
Type of Study: Original Article | Subject: Neurology
Received: 2016/05/29 | Accepted: 2016/12/28 | Published: 2017/06/13
Send email to the article author

Add your comments about this article
Your username or email:

Write the security code in the box >



DOI: 10.22088/cjim.8.3.172


XML     Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Etemadifar M, Jahanbani Ardakani H, Ghaffari S, Fereidan-Esfahani M, Changaei H, Aghadoost N, et al . Cancer risk among patients with multiple sclerosis: A cohort study in Isfahan, Iran. Caspian J Intern Med. 2017; 8 (3) :172-177
URL: http://caspjim.com/article-1-768-en.html
Volume 8, Number 3 (6-2017) Back to browse issues page
Caspian Journal of Internal Medicine
Persian site map - English site map - Created in 0.048 seconds with 807 queries by yektaweb 3471