:: Volume 9, Issue 2 (1-2018) ::
Caspian J Intern Med 2018, 9(2): 189-193 Back to browse issues page
Jak-2 mutation frequency in patients with thrombocytosis
Osman Yokus , Habip Gedik
MD Department of infectious diseases and clinical microbiology, Ministry of Health Bakırköy Sadi Konuk Training and Research Hospital , habipgedik@yahoo.com
Abstract:   (1465 Views)
Background: We aimed to investigate the etiologic causes and the existence of Janus kinase 2  mutation (JAK2) in cases with thrombocytosis.
Methods: In this retrospective study, patients, who were admitted to hematology clinic with thrombocytosis between 2013 and 2015, were investigated in terms of the etiological causes of thrombocytosis and the existence of JAK2 mutation.
Results: We retrospectively evaluated 136 cases that underwent JAK2 mutation analysis due to ET preliminary diagnosis in our hematology clinic. The mean age of the patients was 56.7±15.3 years (range: 22-86 years) and 71 (52%) were males. JAK2 mutation was found to be positive in 58 (42%) of cases. The mean platelet counts of the cases were 860.25×109 / L (range: 455-1,105 109 /L) and the mean spleen vertical length was 135.1±21.6 mm (range: 110-220 mm).
Conclusions: JAK2 mutation analysis and bone marrow biopsy are the two main procedures to diagnose primary thrombocytosis in adults with persistent thrombocytosis after excluding the causes of secondary thrombocytosis. Myeloproliferative neoplasms and essential thrombocytosis are the common causes of primary thrombocytosis in adults with persistent thrombocytosis, as myelodysplastic syndrome rarely causes primary thrombocytosis.

Keywords: Thrombocytosis, Janus kinase 2, Essential thrombocytosis
Full-Text [PDF 208 kb]   (162 Downloads)    
Type of Study: Original Article | Subject: Hematology
Received: 2016/06/20 | Accepted: 2017/10/22 | Published: 2018/01/10



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Volume 9, Issue 2 (1-2018) Back to browse issues page