Promising role for Gc-MAF in cancer immunotherapy: from bench to bedside
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Ehsan Saburi , Amin Saburi , Mostafa Ghanei |
Chemical Injuries Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran , mghaneister@gmail.com |
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Abstract: (10279 Views) |
Immunotherapy has been used for years in many types of cancer therapy. Recently, cancer immunotherapy has focused on mechanisms which can enhance the development of cell-mediated immunity. Anticancer medications are administered to inhibit immunosuppressive factors such as nagalase enzyme, which is produced by neoplastic cells and destroys macrophage activating factor (Gc-MAF). Anti-neoplastics medications can also enhance immune-cell activity against tumors. Such medications show great potential in cancer immunotherapy using natural human mechanisms against neoplasms. |
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Keywords: Cancer, Immunotherapy, Macrophage activating factor, GC-MAF, Vitamin D. |
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Full-Text [PDF 548 kb]
(2114 Downloads)
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Type of Study: Review Article |
Subject:
Oncology Received: 2016/08/22 | Accepted: 2017/03/6 | Published: 2017/07/29
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