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:: دوره 9، شماره 3 - ( 2-1397 ) ::
جلد 9 شماره 3 صفحات 239-243 برگشت به فهرست نسخه ها
Q-T interval prolongation in cirrhosis: Relationship and severity
چکیده:   (632 مشاهده)

Background: Cirrhosis as the final stage of progressive fibrosis of liver can affect other organs such as lungs, kidneys and heart. "Cirrhotic cardiomyopathy" involves the electrophysiological abnormalities such as QT interval prolongation. We assessed correlation between corrected QT interval prolongation and severity of cirrhosis based on Child Classification in each ECG lead.

Methods: In this case-control study, the patients attending the outpatient clinic and inpatient department of internal medicine of Velayat Hospital in Qazvin were enrolled from September 2014 to July 2015. Total samples were 74 patients, half of which were used as controls. Cirrhosis severity was determined as per Child Classification. Both groups had Ca2+, Mg2+, K+ tested and 12- lead ECG was obtained. The QT interval was corrected by two different formulas: (1) QTc=QT/√RR (QTc1); (2) QTc=QT+1.75 (heart rate-60) (QTc2). To analyze the data, the software SPSS Version 16 and Mann-Whitney, Pearson’s chisquare test-Kruskal-Wallis, and t-tests were used.

Results: The mean of QTc1 and QTc2 was longer in cirrhotics than the control group. There was a significant correlation between Child score and length of QTc1 in leads: III (p=0.032), AVL (p=0.041), V2 (p=0.049), V6 (p=0.015). There were significant differences in length of QTc1 in leads: V3 (p=0.031) and V6 (p=0.021); and QTc2 in lead V3 (p=0.039) between Child Classification.

Conclusions: Cirrhosis can induce QTc interval prolongation. Lead V3 has statistically significant correlation with the severity of cirrhosis based on child classification. We propose that QT interval prolongation be added as a criterion for prioritizing liver transplantation.

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نوع مطالعه: Original Article | موضوع مقاله: Internal
دریافت: ۱۳۹۵/۹/۷ | پذیرش: ۱۳۹۶/۷/۲۹ | انتشار: ۱۳۹۷/۲/۱۸
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Hajiaghamohammadi A A, Daee M M, Zargar A, Ahmadi Gooraji S, Rahban A, Attaran F. Q-T interval prolongation in cirrhosis: Relationship and severity . Caspian J Intern Med. 2018; 9 (3) :239-243
URL: http://caspjim.com/article-1-928-fa.html

Q-T interval prolongation in cirrhosis: Relationship and severity . 1. 1397; 9 (3) :239-243

URL: http://caspjim.com/article-1-928-fa.html



دوره 9، شماره 3 - ( 2-1397 ) برگشت به فهرست نسخه ها
Caspian Journal of Internal Medicine
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