%0 Journal Article %A Ala, Shahram %A Saeedi, Majid %A Ghasemi, Arash %A Namdari, Melika %A Koulaeinejad, Neda %T Effect of atorvastatin 1% mouthwash in the prevention of radiotherapy induced mucositis: A pilot study %J Caspian Journal of Internal Medicine %V 13 %N 4 %U http://caspjim.com/article-1-2805-en.html %R 10.22088/cjim.13.4.800 %D 2022 %K Atorvastatin, Mouthwash, Oral mucositis, Radiotherapy, %X Background: Oral mucositis is a troublesome symptom for people who receive radiotherapy and chemotherapy and it is a dose-dependent factor. Atorvastatin is a HMG-CoA reductase inhibitors and various studies have proven its anti-inflammatory effects. The goal of this study was to evaluate atorvastatin 1% mouthwash effects in prevention of radiotherapy-induced mucositis. Methods: Atorvastatin 1% suspension was prepared for mouthwash in this randomized, double-blind clinical trial. Thirty patients randomly received atorvastatin or placebo mouthwash. They had to gargle 5cc of mouthwash, 3 times per day during radiotherapy. The severity and pain of mucositis was evaluated every week, during their treatment. Results: The severity of mucositis between the two study groups was significant every four weeks (p<0.05) and the percentage of patients with more severe mucositis was less in the atorvastatin group. It is found that the pain intensity was lower after 3 and 4 weeks in atorvastatin group. Conclusion: These findings indicated that atorvastatin mouthwash showed a significant activity in relieving of radiotherapy-induced oral mucositis and pain. %> http://caspjim.com/article-1-2805-en.pdf %P 800-804 %& 800 %! Atorvastatin 1% mouthwash and prevention of radiotherapy induced mucositis %9 Short Communication %L A-10-1516-3 %+ Department of radiology and radiation oncology, Faculty of medicine, Mazandaran University of medical science, Sari, Iran %G eng %@ 2008-6164 %[ 2022