RT - Journal Article T1 - Soluble urokinase plasminogen activator receptor (suPAR) in the emergency department: An update JF - babol-caspjim YR - 2022 JO - babol-caspjim VO - 13 IS - 4 UR - http://caspjim.com/article-1-2714-en.html SP - 650 EP - 665 K1 - suPAR K1 - Biomarker K1 - Emergency Department K1 - Mortaliti K1 - Infection K1 - Sepsis AB - Background: The biomarker soluble urokinase plasminogen activator receptor (suPAR) is an indicator of inflammation which is increased in a variety of chronic and acute disease states. Its most promising application in the emergency setting is to aid in the prognostic stratification of patients by identifying those at high risk of deterioration. This is a narrative review of studies evaluating the use of suPAR Methods: We conducted a Medline search for studies on the use of suPAR in patients acutely admitted to the emergency department. Results: 25 original studies were included in the review. suPAR as a marker of inflammation has been used alone or combined to other inflammatory biomarkers in the assessment of patients suffering from various acute and chronic diseases in an emergency setting. As it is non-specific, it may increase in infectious disease, malignancy or acute coronary syndromes among other conditions, but quantitative suPAR levels correlate with disease severity. It may be useful for the identification of high risk patients regardless of underlying pathology. Conclusion: As the ideal biomarker in the emergency setting has not been identified yet, suPAR may be a promising addition to the established biomarkers for the initial assessment of patients in this setting. Additional research is necessary to evaluate the usefulness of suPAR guided management algorithms. LA eng UL http://caspjim.com/article-1-2714-en.html M3 10.22088/cjim.13.4.650 ER -