%0 Journal Article %A Hedayatizadeh-Omran, Akbar %A Janbabaei, Ghasem %A Alizadeh-Navaei, Reza %A Amjadi, Omolbanin %A Mahdavi Izadi, Jeyran %A Omrani-Nava, Versa %T Association between pre-chemotherapy serum levels of vitamin D and clinicopathologic findings in gastric cancer %J Caspian Journal of Internal Medicine %V 11 %N 3 %U http://caspjim.com/article-1-1973-en.html %R 10.22088/cjim.11.3.290 %D 2020 %K Gastric cancer, vitamin D, ELISA, %X Background: To examine the serum levels of vitamin D in newly diagnosed gastric cancer (GC) patients compared with normal subjects and any possible association with prognostic variables. Methods: One-hundred subjects (50 GC and 50 controls) were enrolled and serum vitamin D levels were assessed using ELISA. Based on two definitions, vitamin D was classified as a sufficient level (≥30 ng/dL) and optimal level (25-80 ng/dL). The χ2 and unpaired t-test was used for data analysis with a significance level of 0.05. Results: The mean serum levels of vitamin D in patients and controls were 26.86 (±14.6) and 31.72 (±13.4), respectively (P=0.09). The prevalence of vitamin D insufficiency and deficiency was higher in GC cases than controls (P=0.045 if sufficient level ≥30 and P=0.065 if sufficient level ≥25). According to histological grade analysis, grade 3 patients (poorly differentiated) were found with significantly lower vitamin D concentrations in serum than grade 1 and 2 subjects (22.25 vs 33.29 ng/dL, P=0.021). No significant differences were observed between the two groups in pathological tumor-node-metastasis (pTNM) stages, distant metastasis, and location of the tumor. Conclusion: Higher prevalence of vitamin D insufficiency and deficiency in GC patients may reflect its role in malignancy; however, further studies are needed to confirm this relationship and any possible benefits to the patients.a %> http://caspjim.com/article-1-1973-en.pdf %P 290-294 %& 290 %! Vitamin D in Gastric Cancer %9 Original Article %L A-10-466-2 %+ Gastrointestinal cancer research center, Mazandaran University of Medical Sciences, Sari, Iran. %G eng %@ 2008-6164 %[ 2020