RT - Journal Article T1 - Psoriasis in hyper IgE syndrome – a case report JF - babol-caspjim YR - 2013 JO - babol-caspjim VO - 4 IS - 3 UR - http://caspjim.com/article-1-214-en.html SP - 735 EP - 738 K1 - Hyper IgE syndrome K1 - Psoriasis K1 - Immune deficiency AB - Background: Hyper IgE syndrome (HIES) is a rare primary immune deficiency, described as Job`s syndrome characterized by increased serum levels of IgE, eczema, recurrent cutaneous and pulmonary infections. In this paper, we presented a case of Hyper IgE syndrome.Case Presentation: A 16-year-old Iranian boy presented with a one year history of skin lesions in knees and elbows was diagnosed of psoriasis disease. He had a history of recurrent infections including otitis media, pneumonia, diarrea and skin infection. Laboratory results showed increased level of total IgE and normal in other immunoglobulin. Histologic finding showed hyperkeratosis, parakeratosis of acanthotic epidermis with regular elongation of rete ridges diagnose psoriasis disorder.Conclusion: In conclusion, this is the first case of hyper IgE patient with psoriasis disorder. We addressed the important laboratory findings and actual theories explaining possible association between hyper IgE immunoglobulinemia and psoriasis disorder. LA eng UL http://caspjim.com/article-1-214-en.html M3 ER -