Caspian Journal of Internal Medicine
1
Caspian J Intern Med
Medical Sciences
http://caspjim.com
1
admin
2008-6164
2008-6172
8
10.22088/cjim
14
8888
13
en
jalali
1398
6
1
gregorian
2019
9
1
10
4
online
1
fulltext
en
Factors predicting good outcome of intravenous thrombolysis in stroke patients before rt-PA administration
Neurology
Neurology
Original Article
Original Article
<span style="font-size: 14px;"><span style="font-family: times new roman;"><span style="color: rgb(0, 0, 255);"><strong><em>Background</em></strong><em>:</em></span> To determine whether it is possible to predict intravenous thrombolytic therapy (IVT) outcome after 3 months in acute ischemic stroke patients who are candidate to receive recombinant tissue plasminogen activator (rt-PA), before rt-PA administration based on their risk factors and some available laboratory results.<br>
<span style="color: rgb(0, 0, 255);"><strong><em>Methods</em></strong><em>:</em></span> We enrolled 118 ischemic stroke patients who were treated with standard dose of Alteplase in our hospital. Baseline characteristics, door-to-needle time (DTN), onset-to-treatment time (OTT), the National Institute Health Stroke Scale (NIHSS), systolic and diastolic blood pressure on admission, history of diabetes, hypertension, dyslipidemia, coronary artery disease (CAD), previous ischemic stroke, atrial fibrillation (AF), laboratory results were retrospectively collected. The modified Rankin Scale (mRS) was recorded after 3 months of admission and patients were divided into good (mRS£ 2) and poor (mRS>2) outcome groups. Chi-square test and t-test were used for categorical and continuous variables, respectively. Predictors for outcome after 3 months were studied by multivariable logistic regression.<br>
<span style="color: rgb(0, 0, 255);"><strong><em>Results</em></strong><em>:</em> </span>Good outcome was seen in 60 (51%) patients and poor outcome was seen in 58 (49%) patients. Significant predictors for outcome at 3 months according to multivariable regression analysis were NIHSS score (odds ratio [OR], 0.61; 95% confidence interval [CI], 0.498-0.750; p<0.001), SBP (OR, 0.95; 95% CI, 0.925-0.991; P=0.01), AF (OR, 0.09; 95% CI, 0.013- 0.708; P=0.02), CAD (OR, 17.08; 95% CI, 0.013-0.708; p=0.003).<br>
<span style="color: rgb(0, 0, 255);"><strong><em>Conclusion</em></strong><em>:</em></span> Higher NIHSS score, higher SBP on admission, AF and history of CAD could be the independent predictors of outcome after IVT in acute ischemic stroke patients.</span></span>
ischemic stroke, thrombolytic therapy, rt-PA
424
430
http://caspjim.com/browse.php?a_code=A-10-1210-1&slc_lang=en&sid=1
Masoud
Mehrpour
Dr.MasoudMehrpour@gmail.com
100319475328460018840
100319475328460018840
No
Department of Neurology, Firoozgar Hospital, Iran University of Medical Sciences, (IUMS), Tehran, Iran
Motahareh
Afrakhteh
mt_afrakhte@yahoo.com
100319475328460018841
100319475328460018841
No
Department of Neurology, Firoozgar Hospital Iran, University of Medical Sciences (IUMS) Tehran, Iran
Seyedeh Fahimeh
Shojaei
shojaee.fahimeh@yahoo.com
100319475328460018842
100319475328460018842
No
Firoozgar Clinical Research and Development Center(FCRDC), Iran University of Medical Sciences(IUMS) , Tehran,Iran
Ahmad
Sohrabi
ahmadsohrabi1368@gmail.com
100319475328460018843
100319475328460018843
No
Infectious disease research center, Golestan University of Medical Sciences, Gorgan, Iran
Rezan
Ashayeri
re.Ashayeri@gmail.com
100319475328460018844
100319475328460018844
No
Department of Neurology, Firoozgar Hospital Iran, University of Medical Sciences (IUMS) Tehran, Iran
Sara
Esmaeili
sara.es64@gmail.com
100319475328460018845
100319475328460018845
No
Department of Neurology, Firoozgar Hospital Iran, University of Medical Sciences (IUMS) Tehran, Iran
Maryam
Bahadori
Maryam.bahadori.1987@gmail.com
100319475328460018846
100319475328460018846
Yes
Department of Neurology, Firoozgar Hospital, Iran University of Medical Sciences(IUMS), Tehran, Iran