Caspian Journal of Internal Medicine
1
Caspian J Intern Med
Medical Sciences
http://caspjim.com
1
admin
2008-6164
2008-6172
8
10.22088/cjim
14
8888
13
en
jalali
1398
10
1
gregorian
2020
1
1
11
1
online
1
fulltext
en
A systematic review and meta-analysis on the association of serum and tumor tissue iron and risk of breast cancer
Oncology
Oncology
Review Article
Review Article
<span style="font-size:14px;"><span style="font-family:times new roman;"><span style="color:#0000FF;"><strong><em>Background</em></strong><em>:</em></span> Some studies have investigated the effects of iron on breast carcinogenesis and reported different findings about the association between Fe and breast cancer risk. This study was conducted to estimate this effect using meta-analysis method.<br>
<span style="color:#0000FF;"><strong><em>Methods</em></strong><em>:</em></span> A total of 20 articles published between 1984 and 2017 worldwide were selected through searching PubMed, Scopus, Embase, Web of Science, and Cochrane Library. Keywords such Breast Cancer, Neoplasm, Trace elements, Iron, Breast tissue concentration, Plasma concentration, Scalp hair concentration, toenail concentration and their combination were used in the search.<br>
<span style="color:#0000FF;"><strong><em>Results</em></strong><em>:</em> </span>The total number of participants was 4,110 individuals comprising 1,624 patients with breast cancer and 2,486 healthy subjects. Fe concentration was measured in the various subgroups in both case and control groups. There were significant correlations between Fe concentration and breast cancer in breast tissue subgroup (SMD: 0.67 [95% CI: 0.17 to 1.17; P=0.009]). Whereas, there was no meaningful difference in Fe status between women with and without breast cancer related to scalp hair and plasma subgroups; (SMD: -3.74 [95% CI: -7.58 to 0.10; P=0.056] and (SMD:-1.14[95% CI: -2.30 to 0.03; P=0.055], respectively.<br>
<span style="color:#0000FF;"><strong><em>Conclusion</em></strong><em>:</em> </span>The present meta-analysis indicated a positive and straight association between iron concentrations and risk of breast cancer but because of high heterogeneity we recommend more accurate future studies</span></span>
Breast Cancer, trace elements, Iron, Meta-analysis.
1
11
http://caspjim.com/browse.php?a_code=A-10-1275-1&slc_lang=en&sid=1
Akram
Sanagoo
sanagoo@goums.ac.ir
100319475328460019877
100319475328460019877
No
Nursing Research Center, Golestan University of Medical Sciences, Gorgan, Iran
Faezeh
Kiani
fkiani43@yahoo.com
100319475328460019878
100319475328460019878
No
Student Research Committee, Ilam University of Medical Sciences, Ilam, Iran
Marzieh
Saei Gharenaz
saeigarenaz@gmail.com
100319475328460019879
100319475328460019879
No
Students Research Committee, Shahid Beheshti University of Medical Sciences, Tehran, Iran
Fatemeh
Sayehmiri
fsayehmiri@yahoo.com
100319475328460019880
100319475328460019880
No
Student Research Committee, Proteomics Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
Fatemeh
koohi
fkoohi92@gmail.com
100319475328460019881
100319475328460019881
No
Social Determinants of Health Research Center, Birjand University of Medical Sciences, Birjand, Iran
Leila
Jouybari
jouybari@goums.ac.ir
100319475328460019882
100319475328460019882
Yes
Nursing Research Center, Golestan University of Medical Sciences, Gorgan, Iran
Majid
Dousti
m.dousti65@yahoo.com
100319475328460019883
100319475328460019883
No
Faculty of Medicine, Ilam University of Medical Sciences, Ilam, Iran