Caspian Journal of Internal Medicine
1
Caspian J Intern Med
Medical Sciences
http://caspjim.com
1
admin
2008-6164
2008-6172
8
10.22088/cjim
14
8888
13
en
jalali
1390
10
1
gregorian
2012
1
1
3
4
online
1
fulltext
en
Evaluation of the need for treatment on 72 subjects with anti-HBe positive chronic hepatitis B
Infectious Diseases
Infectious Diseases
Original Article
Original Article
Background: Viral load and alanine aminotransferase (ALT) levels may not be the key points for making a decision in the treatment of anti-HBe positive chronic hepatitis B. The purpose of this study was to assess the histological evaluation of liver to find the need for treatment on 72 patients with anti-HBe positive chronic hepatitis B. <br> Methods: The liver biopsy slides of the 72 patients (56 subjects with viral load >10<sup>5</sup> with any ALT levels, 16 cases with viral load <10<sup>5</sup> copies/ml with abnormal ALT levels) were evaluated at the Department of Pathology, Babol University of Medical Sciences, Iran from April 2006 to August 2011. Ishak Scoring system was used to determine the hepatitis activity index (HAI) and fibrosis score. Those with total score >3 were considered for treatment. Data were collected and analyzed. <br>Results: The mean age of the patients was 34.4±12 years. The mean ALT level was 105±10.5 IU/L. The mean HAI with viral loads more or less than >10<sup>5</sup> was 5.9±2.6 and 4±1.9, respectively (p=0.04). HAI >3 was seen in 9 (56.3%) and in 43 (76.8%) subjects with viral loads <10<sup>5</sup> and > 10<sup>5</sup> copies/ml (p<0.05). No fibrosis was seen in 25 (34.7%) of these cases. Fibrosis stage regarding viral loads more or less than10<sup>5</sup> copies/ml was equal (p=0.12). The need for treatment was seen in 62 (86%) patients. <br>Conclusion: The results show that any viral load values may cause significant injuries that need to treatment. Liver biopsy is indicated in any case of anti-HBe with any viral loads with increased ALT levels.
Hepatitis activity index, Fibrosis, Treatment, Viral load
519
522
http://caspjim.com/browse.php?a_code=A-10-62-109&slc_lang=en&sid=1
Shima
Soleimani Amiri
1003194753284600644
1003194753284600644
Yes
Shariar
Shafaee
1003194753284600645
1003194753284600645
No
Mohammad Reza
Hasanjani Roushan
1003194753284600646
1003194753284600646
No
Masomeh
Baiani
1003194753284600647
1003194753284600647
No
Mahmoud
Hajiahmadi
1003194753284600648
1003194753284600648
No