Caspian Journal of Internal Medicine
1
Caspian J Intern Med
Medical Sciences
http://caspjim.com
1
admin
2008-6164
2008-6172
8
10.22088/cjim
14
8888
13
en
jalali
1399
3
1
gregorian
2020
6
1
11
4
online
1
fulltext
en
Protective effect of lycopene on oral mucositis and antioxidant capacity of blood plasma in the rat exposed to gamma radiation
Dentistry
Dentistry
Original Article
Original Article
<span style="font-size:14px;"><span style="font-family:Times New Roman;"><strong><em><span style="color:#0000ff;">Background:</span></em> </strong>Nowadays, radiotherapy is used effectively for treatment of head and neck cancers. Mucositis is one of the most important side effects of radiotherapy. Radio-protective agents protect tissues and cells against the adverse effects due to ionizing radiation and cleave radiation-induced free radicals. Lycopene as a potent antioxidant protects cells against oxidative damage by free radical–scavenging. The present study investigated the antioxidant effect of lycopene on oral mucosa of irradiated rats.<span dir="RTL"></span><br>
<strong><em><span style="color:#0000ff;">Methods:</span></em> </strong>In this experimental animal study, 28 rats were placed in four groups as follows: treated with 50 mg /kg of lycopene (L50), solvent+irradiation (SR), 25 mg / kg of lycopene+irradiation (LR25), and 50 mg / kg of lycopene+irradiation (LR50). The rats received lycopene intraperitoneally. On the irradiation day (day 0) and tenth day of radiation, blood samples were taken from the animals for FRAP and TBARS tests.<strong><span dir="RTL"></span></strong><br>
<strong><em><span style="color:#0000ff;">Results:</span></em> </strong>The results showed that the LR50 group didn’t show mucositis higher than Grade 2. There was a significant difference (p <0.05) between SR and the L50 regarding the severity of mucositis. In addition, L50 showed higher antioxidant activity and lower peroxidation than SR. <span dir="RTL"></span><br>
<strong><em><span style="color:#0000ff;">Conclusion:</span></em> </strong>The lycopene reduced the severity of mucositis. Therefore, it can be used as a potential and promising nutritional substance to prevent radiotherapy complications, especially in the treatment of head and neck cancers. However, further research is necessary to confirm these results.<span dir="RTL"></span><br>
</span></span>
Antioxidant activity, Irradiation, Lycopene, Mucositis, Radiotherapy
419
425
http://caspjim.com/browse.php?a_code=A-10-1665-1&slc_lang=en&sid=1
Mina
Motallebnejad
mmotallebnejad@yahoo.com
100319475328460024939
100319475328460024939
No
Oral Health Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran
Shaghayegh
Zahedpasha
shaqayeq.zahedpasha@gmail.com
100319475328460024940
100319475328460024940
No
Department of Oral Medicine, Faculty of Dentistry, Mazandaran University of Medical Science, Sari, Iran
Ali Akbar
Moghadamnia
moghadamnia@gmail.com
100319475328460024941
100319475328460024941
No
Cellular and Molecular Biology Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran
Sohrab
Kazemi
kazemi.msm@gmail.com
100319475328460024942
100319475328460024942
No
Cellular and Molecular Biology Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran
Daryoush
Moslemi
d_moslemi@yahoo.com
100319475328460024943
100319475328460024943
No
Cancer Research Center, Health Research Institute. Babol University of Medical Sciences, Babol, Iran.
Mahdi
Pouramir
pouramir@yahoo.com
100319475328460024944
100319475328460024944
No
Cellular and Molecular Biology Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran
Fariba
Asgharpour
f_asgharpour@yahoo.com
100319475328460024945
100319475328460024945
Yes
Dental Materials Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran