Caspian Journal of Internal Medicine
1
Caspian J Intern Med
Medical Sciences
http://caspjim.com
1
admin
2008-6164
2008-6172
8
10.22088/cjim
14
8888
13
en
jalali
1399
12
1
gregorian
2021
3
1
12
2
online
1
fulltext
en
The Role of microRNA in Cancer Cachexia and Muscle Wasting: A Review Article
Oncology
Oncology
Review Article
Review Article
<span style="font-size:14px;"><span style="font-family:Times New Roman;">Almost half of cancer patients experience cachexia syndrome. Cachexic patients are at risk of increased side effects of chemotherapy, reduced tolerance to chemotherapy drugs, longer duration of treatment period, and decreased quality of life. Cancer cachexia is a multifactorial syndrome. Micro ribonucleic acid (miRNA), a “non-coding RNA”, is considered to be a risk factor of cachexia and muscle wasting in cancer patients. miRNA has a role in affecting protein regulation, associated with different inflammatory and disease pathways. miRNA can also affect cytokines or directly change the regulation of metabolism that lead to cachexia. In this review, we want to focus on the pathophysiology to give a better understanding about the role of miRNA in the development of cancer cachexia. Based on various pathways of miRNA in cancer cachexia, it can be a potential target for therapeutic strategies. Improved knowledge about miRNA can give the opportunity to develop new treatment in the management of cancer cachexia.</span></span>
micro RNA, cancer, cachexia, muscle wasting
124
128
http://caspjim.com/browse.php?a_code=A-10-1485-2&slc_lang=en&sid=1
Noorwati
Sutandyo
noorwatisoetandyo@gmail.com
100319475328460028129
100319475328460028129
Yes
Hematology and Medical Oncology Division, Dharmais National Cancer Centre Hospital, Jakarta, Indonesia