Caspian Journal of Internal Medicine
1
Caspian J Intern Med
Medical Sciences
http://caspjim.com
1
admin
2008-6164
2008-6172
8
10.22088/cjim
14
8888
13
en
jalali
1399
8
1
gregorian
2020
11
1
11
Covid 19 Supplement 1
online
1
fulltext
en
Diagnostic value of chest CT in Iranian patients with suspected COVID-19
Infectious Diseases
Infectious Diseases
Original Article
Original Article
<span style="font-size:14px;"><span style="font-family:Times New Roman;"><span style="color:#0000ff;"><strong><em>Background:</em></strong></span> In the current COVID-19 pandemic, there is a rising need for a rapid and reliable diagnostic tool. We hypothesized that chest computed tomography (CT) can be a potential alternative for reverse transcription-polymerase chain reaction (RT-PCR).<br>
The aim of this study was to compare the diagnostic value of chest CT and RT-PCR in Iranian patients with suspected COVID-19.<br>
<span style="color:#0000ff;"><em><strong>Methods: </strong></em></span>In a retrospective, single-center case series, 568 consecutive hospitalized or outpatient patients with suspected COVID-19 underwent chest CT and/or RT-PCR testing at Imam Reza Hospital, the tertiary teaching hospital of Tabriz University of Medical Sciences in Iran, from February 21 and March 28, 2020.<br>
<strong><span style="color:#0000ff;"><em>Results:</em></span> </strong>The sensitivity of chest CT for signifying COVID-19 was 64% (95% CI: 56%–71%) on the basis of positive RT-PCR results as a standard method. CT imaging also had a specificity of 77% (95% CI: 73%–81%), positive predictive value of 35% (95% CI: 0.31–0.39), negative predictive value of 66% (95% CI: 0.61–0.69), positive likelihood ratio of 2.79 (95% CI: 2.26–3.46), and negative likelihood ratio of 0.47 (95% CI: 0.38–0.57).<br>
<span style="color:#0000ff;"><em><strong>Conclusion:</strong></em></span><strong> </strong>Chest CT had higher specificity than RT-PCR in the diagnosis of COVID-19<del cite="mailto:MRT%20www.Win2Farsi.com" datetime="2020-09-21T21:52">, </del><ins cite="mailto:MRT%20www.Win2Farsi.com" datetime="2020-09-21T21:52">. </ins>Therefore, it can play a crucial role in the early diagnosis. Similar to the previous studies, the typical CT features were patchy ground-glass opacities as well as peripheral aspects of the lungs consolidations.</span></span>
Sensitivity, Specificity, Chest CT, RT-PCR, COVID-19
527
530
http://caspjim.com/browse.php?a_code=A-10-1835-1&slc_lang=en&sid=1
Hanieh
Salehi-Pourmehr
poormehrh@yahoo.com
100319475328460026219
100319475328460026219
No
Research center for Evidence-Based- Medicine, Iranian EBM Center: A Joanna Briggs Institute (JBI) Center of Excellence, Tabriz University of Medical Sciences, Tabriz, Iran.
Hojjat
Pourfathi
hojjatpourfathi@yahoo.com
100319475328460026220
100319475328460026220
No
Department of Anesthesiology, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran
Mohammad Kazem
Tarzamni
tarzamni@yahoo.com
100319475328460026221
100319475328460026221
No
Radiology Department, Medical Radiation Sciences Research Group, Imam Reza Hospital, Tabriz University of Medical Sciences, Tabriz, Iran
Morteza
Ghojazadeh
Ghojazadehm@tbzmed.ac.ir
100319475328460026222
100319475328460026222
No
Research center for Evidence-Based- Medicine, Iranian EBM Center: A Joanna Briggs Institute (JBI) Center of Excellence, Tabriz University of Medical Sciences, Tabriz, Iran.
Behrooz
Naghili
naghilib@tbzmed.ac.ir
100319475328460026223
100319475328460026223
No
Research Center for Infectious and Tropical Disease, Tabriz University of Medical Sciences, Tabriz, Iran
Armin
Zarrintan
zarrintanarmin@gmail.com
100319475328460026224
100319475328460026224
No
Department of Radiology, Imam Reza Hospital, Tabriz University of Medical Sciences, Tabriz, Iran
Reza
Mehdipour
Mehdipourr@yahoo.com
100319475328460026225
100319475328460026225
No
Research center for Evidence based- medicine, Tabriz University of Medical Sciences, 5166614756, Tabriz, Iran.
Sakineh
Hajebrahimi
hajebrahimis@gmail.com
100319475328460026226
100319475328460026226
Yes
Research center for Evidence-Based- Medicine, Iranian EBM Center: A Joanna Briggs Institute (JBI) Center of Excellence, Tabriz University of Medical Sciences, Tabriz, Iran.