en Infectious Diseases Infectious Diseases Review Article Review Article <span style="font-size:14px;"><span style="font-family:Times New Roman;"><strong><span style="color:#0033ff;"><em>Background:</em></span> </strong>Since the outbreak of COVID-19, various treatments have been frequently reported for patients infected with this virus, especially in transplant patient recipients. Investigating o the literature and organ transplant patients&nbsp;with COVID-19, it could pave the way to understanding, handling, and treatment of COVID-19.<br> <span style="color:#0033ff;"><em><strong>Methods:&nbsp;</strong></em></span>We had a brief review of the literature on immunosuppressive therapy in kidney transplants infected with COVID-19 based on the PubMed Database by keywords &ldquo;kidney, transplant, COVID-19, and immunosuppress&rdquo; after hospitalization&nbsp;of a kidney transplant reception infected with COVID-19. He&nbsp;had already been recorded in the Organ Transplant Registry (ID&ne; 64510) of Tabriz University of Medical Sciences /Iran.<br> <span style="color:#0033ff;"><em><strong>Results:</strong>&nbsp;</em></span>We reported the clinical course of a 45-year-old man with a history of kidney transplant and immunotherapy who was infected with COVID-19 with&nbsp;respiratory infections&nbsp;and positive RT-PCR (Real-time polymerase chain reaction).&nbsp;He was treated with hydroxychloroquine, Kaletra, Cellcept, and Prednisolone for 5 days, and finally discharged from the hospital. In addition, the reviewing of&nbsp;48 papers with 745 samples showed that immunosuppressant medications alone could be a therapeutic choice in kidney transplants infected with COVID-19&nbsp;with careful management.<br> <em><span style="color:#0033ff;"><strong>Conclusion:</strong></span></em>&nbsp;The patients with organ transplantation infected with COVID-19 may show different clinical signs, clinical course, and prognosis due to underlying diseases and the use of immunosuppressant medications.&nbsp;It might be best to continue taking the immunosuppressant medications but to modify them based on patients conditions such as clinical symptoms, laboratory results, paraclinical examinations.</span></span> COVID- 19, Kidney transplant, Immunosuppressant, Review 161 172 http://caspjim.com/browse.php?a_code=A-10-1446-2&slc_lang=en&sid=1 Zahra Sheikhalipour sheikhalipourz@tbzmed.ac.ir 100319475328460035658 100319475328460035658 No 1. Medical and Surgical Department, Nursing and Midwifery School, Organ Transplant Registry, Tabriz University of Medical Sciences, Iran Masood Faghihdinevari masood.dinevar@gmail.com 100319475328460035659 100319475328460035659 No Liver and Gastrointestinal Diseases Research Center, Organ Transplant Registry, Tabriz University of Medical Sciences, Tabriz, Iran Hanieh Salehi-Pourmehr poormehr@yahoo.com 100319475328460035660 100319475328460035660 No Research Center for Evidence-Based Medicine, Iranian EBM Centre: A Joanna Briggs Institute (JBI) Center of Excellence, Tabriz University of Medical Sciences, Tabriz, Iran Maryam Khameneh mary.khamene@gmail.com 100319475328460035661 100319475328460035661 No Student Research Committee, Islamic Azad University of Tabriz, Tabriz, Iran Leila Vahedi vahedi.l49@gmail.com 100319475328460035662 100319475328460035662 Yes Liver and Gastrointestinal Diseases Research Center, Organ Transplant Registry, Tabriz University of Medical Sciences, Tabriz, Iran