Caspian Journal of Internal Medicine
1
Caspian J Intern Med
Medical Sciences
http://caspjim.com
1
admin
2008-6164
2008-6172
8
10.22088/cjim
14
8888
13
en
jalali
1400
10
1
gregorian
2022
1
1
13
1
online
1
fulltext
en
Effect of Oral and parenteral routes of vitamin D supplementation on serum 25(OH) vitamin D levels in patients with non-alcoholic fatty liver disease
Internal
Internal
Original Article
Original Article
<span style="font-size:14px;"><span style="font-family:Times New Roman;"><span style="color:#0000ff;"><strong><em>Background</em></strong><em>:</em></span> Due to the interruption of the EHC pathway in NAFLD patients, we hypothesized that parenteral vitamin D supplementation is superior to oral in vitamin D insufficient patients with NAFLD. Therefore, this study aimed to compare the efficacy of oral and parenteral routes of vitamin D supplementation on serum 25(OH) vitamin D levels in patients with NAFLD.<br>
<span style="color:#0000ff;"><strong><em>Methods</em></strong><em>:</em></span> In this prospective randomized trial, 66 NAFLD cases with vitamin D deficiency were studied. For 33 cases, oral vitamin D was supplemented, whereas the other 33 patients were given an intramuscular injection of vitamin D<em>. </em>Laboratory tests and liver ultrasound were performed at the beginning and the end of the trial for each subject.<br>
<span style="color:#0000ff;"><strong><em>Results</em></strong><em>:</em></span> Regardless of the drug administration route, at the end of this trial the mean of serum 25-hydroxy vitamin D level increased from 8.74±2.47 to 33.16±17.61 (P=0.00), and the mean±SD for serum triglyceride decreased from 191.46±92.79 to 166.00±68.30 (P=0.02), both were statistically significant. Liver ultrasound reported statistically significant changes in the grade of fatty liver disease (P=0.003). In the comparison between the two groups, serum 25-hydroxy vitamin D level changes were not statistically significant (P=0.788).<br>
<span style="color:#0000ff;"><strong><em>Conclusion</em></strong><em>:</em></span> The intramuscular method of supplementation was not better than the oral route in improving serum 25(OH) vitamin D levels in NAFLD patients. In this study, the impaired EHC and vitamin D absorption inhibitor factors in NAFLD patients did not affect the final result of serum vitamin D levels significantly.</span></span>
Nonalcoholic fatty liver disease, Vitamin D, Routes of administration
23
28
http://caspjim.com/browse.php?a_code=A-10-2144-1&slc_lang=en&sid=1
Arezou
Hamzehzadeh Alamdari
alamdari.arezou@gmail.com
100319475328460033282
100319475328460033282
Yes
Gastroenterology and Liver Diseases Research Center, Department of Internal Medicine, Tabriz University of Medical Sciences, Tabriz, Iran
Samira
Ahrabi
samira.araqchinahrabi@gmail.com
100319475328460033283
100319475328460033283
No
Gastroenterology and Liver Diseases Research center, Department of Internal Medicine, Tabriz University of Medical Sciences, Tabriz, Iran
Manouchehr
Khoshbaten
mkhoshbaten@yahoo.com
100319475328460033284
100319475328460033284
No
Gastroenterology and Liver Diseases Research center, Department of Internal Medicine, Tabriz University of Medical Sciences, Tabriz, Iran
Shahram
Roustaei
roustaei_shahram@yahoo.com
100319475328460033285
100319475328460033285
No
ِِDepartment of Surgery, Tehran University of Medical Sciences, Tehran, Iran
Sara
Araqchin Ahrabi
ahrabisara0@gmail.com
100319475328460033286
100319475328460033286
No
Gastroenterology and Liver Diseases Research center, Department of Internal Medicine, Tabriz University of Medical Sciences, Tabriz, Iran
Mohammad
Asghari Jafarabadi
m.asghari862@gmail.com
100319475328460033287
100319475328460033287
No
Department of Statistics and Epidemiology, School of Medicine, Zanjan University of Medical Sciences, Zanjan, Iran