Caspian Journal of Internal Medicine
1
Caspian J Intern Med
Medical Sciences
http://caspjim.com
1
admin
2008-6164
2008-6172
8
10.22088/cjim
14
8888
13
en
jalali
1400
11
1
gregorian
2022
2
1
13
2
online
1
fulltext
en
Can cytokines response play a role in the treatment of fatal leptospirosis?
Infectious Diseases
Infectious Diseases
Original Article
Original Article
<span style="font-size:14px;"><span style="font-family:Times New Roman;"><span style="color:#0000ff;"><em><strong>Background: </strong></em></span>The northern coastal regions of Iran are endemic for leptospirosis which may range from a subclinical illness to a progressively fatal disease. There has been growing evidence that inflammatory markers play a significant role in the severity and prognosis of leptospirosis. This study aimed to investigate inflammatory cytokines in patients with leptospirosis.<br>
<em><span style="color:#0000ff;"><strong>Methods: </strong></span></em>This descriptive-analytical prospective study was performed in 75 patients over 18 years old who had a positive microscopic agglutination test (MAT) titer from January to June 2019. SPSS software Version 20 was used for statistical analysis and the significance level was considered as p<0.05<span dir="RTL">.</span><br>
<strong><em><span style="color:#0000ff;">Results:</span></em> </strong>The patients’ age enrolled in this study are from 21 to 75 years with a mean and standard deviation of 48.6 ± 14.0. The male to female ratio in our participants was 54/21. Fever was the most common symptoms in 66 (88.0%) patients, followed by myalgia in 62 (82.7%) cases. The level of interleukin 10 was significantly higher in severe illness (P=0.003) and fatal cases (p<0.028) compared with recovered patients. The level of TNF-α level was also higher in the severe illness and Weil's syndrome compared with the mild kind (P=0.022).<br>
<span style="color:#0000ff;"><em><strong>Conclusion: </strong></em></span>Our results showed that the levels of TNF-α and IL-10 significantly increased in severe leptospirosis. Also, IL-10 was significantly higher in fatal cases. The inhibition of IL-10 production might play an important role in decreasing the risk of fatal outcomes in leptospirosis.</span></span>
Leptospirosis, Inflammatory cytokine, treatment, outcome, IL10
343
348
http://caspjim.com/browse.php?a_code=A-10-2136-2&slc_lang=en&sid=1
Ahmad
Alikhani
ahalikhani@yahoo.com
100319475328460036499
100319475328460036499
No
Department of Infectious Diseases, Antimicrobial resistance research center and communicable disease institute, Mazandaran University of Medical Sciences, Sari, Iran
Kimia
Mahmoodi
edu.kimiamahmoodi93@yahoo.com
100319475328460036500
100319475328460036500
No
Leila
Delavaryan
Leiladelavaryan@yahoo.com
100319475328460036501
100319475328460036501
No
Ebrahim
Salehifar
esalehifar52@gmail.com
100319475328460036502
100319475328460036502
No
Department of clinical Pharmacy, School of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran.
Ali Reza
Rafiei
rafiei1710@gmail.com
100319475328460036503
100319475328460036503
No
Department of Immunology, School of Medicine, Mazandaran University of Medical Sciences, Sari, Iran.
Mahmoud
Sadeghi Zavare
drm_sadeghihz@yahoo.com
100319475328460036504
100319475328460036504
Yes
Infectious Diseases and Tropical Medicine Research Center, Babol University of Medical Sciences, Babol