en psychiatry psychiatry Case Series Case Series <span style="font-size:14px;"><span style="font-family:Times New Roman;"><span style="color:#0000ff;"><em><strong>Background: </strong></em></span>Coronavirus disease 2019 (COVID-19) involves different organs and clinical presentations varying from respiratory symptoms to gastrointestinal symptoms and neurological symptoms. Another group of symptoms are psychiatric symptoms and according to a study, 53.8% of participants reported various degrees of these symptoms.<br> <span style="color:#0000ff;"><em><strong>Case Presentation:</strong></em></span> In this study, we presented six cases with sudden onset OCD or exacerbation of the previously controlled OCD concomitant with COVID-19 symptoms.Obsessive compulsive symptoms can be the presenting manifestation of COVID-19.<br> <span style="color:#0000ff;"><strong><em>Conclusion:</em> </strong></span>The neuropsychiatric manifestations may be resulted from central nervous system (CNS) infiltration, and dysregulation of inflammatory factors autoimmune responses.</span></span> COVID-19, Obsessive compulsive disorder, Neuropsychiatric presentation 259 263 http://caspjim.com/browse.php?a_code=A-10-2244-1&slc_lang=en&sid=1 Mahsa Owji Mahsa.owji@gmail.com 100319475328460035573 100319475328460035573 No Multiple Sclerosis Research Center; Neuroscience institute; Tehran University of Medical Sciences; Tehran; Iran Abdorreza Naser Moghadasi abdorrezamoghadasi@gmail.com 100319475328460035574 100319475328460035574 No Multiple Sclerosis Research Center; Neuroscience institute; Tehran University of Medical Sciences; Tehran; Iran Faezeh Gholamian fa.gholamian@gmail.com 100319475328460035575 100319475328460035575 No Department of Psychiatry, Roozbeh Psychiatric Hospital, Tehran University of Medical Sciences, Tehran, Iran Seyed Yaser Mousavi yaser135778@yahoo.com 100319475328460035576 100319475328460035576 Yes Department of Psychiatry, Children’s Medical center, Tehran University of Medical Sciences, Tehran, Iran