Caspian Journal of Internal Medicine
1
Caspian J Intern Med
Medical Sciences
http://caspjim.com
1
admin
2008-6164
2008-6172
8
10.22088/cjim
14
8888
13
en
jalali
1401
6
1
gregorian
2022
9
1
13
4
online
1
fulltext
en
Association of serum calcium levels with infarct volume and stroke scores in acute ischemic stroke patients: An observational study
Cardiology
Cardiology
Original Article
Original Article
<span style="font-size:14px;"><span style="font-family:Times New Roman;"><span style="line-height:14pt"><b><i><span style="color:blue">Background</span></i></b><i><span style="color:blue">:</span></i> <span style="background:white">Stroke vastly contributes to death and disability worldwide. Acute ischemic stroke (AIS) is caused by a reduction in supply of blood to the brain. Accumulation of unnecessary intracellular serum calcium in AIS induces the cytotoxic actions that activates enzymes involved in cell death. The present investigation assessed the relationship of total serum calcium level (at admission) and initial diffusion weighted imaging (DWI) infarct volume and correlated with National Institute of Health Stroke Scale (NIHSS) scores.</span><span style="font-size:9.0pt"></span></span><br>
<span style="line-height:14pt"><b><i><span style="color:blue">Methods:</span></i></b> <span style="background:white">A hospital-based observational study was conducted on 74 consecutive patients identified with AIS fulfilling the inclusion criteria. NIHSS scores and serum ionized calcium </span></span></span></span><span style="font-size:12pt"><span style="line-height:14pt"><span new="" roman="" style="font-family:" times=""><w:sdt id="327867149" sdttag="goog_rdk_0"></w:sdt><w:sdt id="-590702664" sdttag="goog_rdk_1"></w:sdt></span></span></span><span style="font-size:14px;"><span style="font-family:Times New Roman;"><span style="line-height:14pt"><span style="background:white">were calculated in every patient and compared with DWI infarct volume for assessing correlation between these three. Statistical software R Version 4.0.2 and Microsoft Excel were used for statistical analysis.</span><span style="font-size:10.0pt"></span></span><br>
<span style="line-height:14pt"><b><i><span style="color:blue">Results:</span></i></b> <span style="background:white">Out of the 74 patients, most of them were in age group of 50-69 years, with a male preponderance (68.9%). </span>A significant association was noticed between diabetes and dyslipidemia with age (P=0.01499). <span style="background:white">A strong negative correlation was observed between NIHSS scores (at admission & discharge) with ionized calcium, while a strong positive correlation was noticed between stroke scores with infarct volume. A statistically significant negative correlation was recorded between serum calcium (on admission) and infarct size (r=-0.851755, P=0.0001). The mean of NIHSS scores on admission (8.24±5.19) has been remarkably higher when compared with NIHSS scores at discharge (5.25±3.89).</span><b><i><span style="color:blue"></span></i></b></span><br>
<span style="line-height:14pt"><b><i><span style="color:blue">Conclusion</span></i></b><i><span style="color:blue">:</span></i> <span style="background:white">In patients with AIS examined within 6-24 hours of symptoms onset, serum ionized calcium and volume of infarct on DWI showed inverse association. Serum calcium serves as a marker of severity and acts as prognostic factor in AIS.</span><b><i><span style="color:#0033cc"></span></i></b></span></span></span>
Acute Stroke, Serum Calcium, NIHSS Score, Infarct Size, Prognosis
780
785
http://caspjim.com/browse.php?a_code=A-10-2400-1&slc_lang=en&sid=1
Ramya R
Nayak
ramyagirish69@yahoo.com
100319475328460039896
100319475328460039896
Yes
Department of General Medicine, Ramaiah Medical College and Hospital, Bengaluru 560 054, Karnataka, India
Srikanth
Narayanaswamy
msrstrep@gmail.com
100319475328460039897
100319475328460039897
No
Department of General Medicine, Ramaiah Medical College and Hospital, Bengaluru 560 054, Karnataka, India