Caspian Journal of Internal Medicine

en Comparison of long-pulsed alexandrite laser and topical tretinoin-ammonium lactate in axillary acanthosis nigricans: A case series of patients in a before-after trial Dermathology Dermathology Case Series Case Series Background: Acanthosis nigricans (AN) is a brown to black, velvety hyperpigmentation of the skin that usually involves cutaneous folds. Treatment of AN is important regarding cosmetic reasons and various therapeutic modalities have been used for these purposes. The goal of this study was to compare the effectiveness of long-pulsed alexandrite laser and topical tretinoin-ammonium lactate for treatment of axillary-AN. Methods: Fifteen patients with bilateral axillary-AN were studied in Razi Hospital, Tehran, Iran. Diagnosis was confirmed by two independent dermatologists. Each side skin lesion was randomly allocated to either topical mixed cream of tretinoin 0.05%- ammonium lactate 12% or long-pulsed alexandrite laser. Duration of treatment was 14 weeks. At endpoint, the mean percent reduction from baseline in pigmentation area was compared between the two groups. Results: The study population consisted of 15 patients, three males and 12, females. The mean age of patients was 28.5±4.9 years. The mean percent reduction was 18.3±10.6%, in tretinoin/ammonium lactate group and 25.7±11.8% in laser group (P=0.004). Conclusion: These findings indicate that the application of alexandrite laser is a relative effective method for treatment of axillary-AN. However, this issue requires further studies with prolonged follow-up period. Acanthosis nigricans, Long-pulsed alexadrite laser, Tretinoin, Ammonium Lactate 290 293 http://caspjim.com/browse.php?a_code=A-10-170-3&slc_lang=en&sid=1 Amirhoshang Ehsani ehsanih@sina.tums.ac.ir 10031947532846006729 10031947532846006729 No Department of Dermatology, Razi Hospital, Tehran University of Medical Sciences (TUMS), Tehran, Iran. Pedram Noormohammadpour normohamad@razi.tums.ac.ir 10031947532846006730 10031947532846006730 No Department of Dermatology, Razi Hospital, Tehran University of Medical Sciences (TUMS), Tehran, Iran. Azadeh Goodarzi azadeh_goodarzi1984@yahoo.com 10031947532846006731 10031947532846006731 No Department of Dermatology, Rasul Akram Hospital, Iran University of Medical Sciences (IUMS), Tehran, Iran. Mostafa Mirshams-Shahshahani mirshams-m@yahoo.com 10031947532846006732 10031947532846006732 No Department of Dermatology, Razi Hospital, Tehran University of Medical Sciences (TUMS), Tehran, Iran. Seyyed-Pardis Hejazi pardis.hegazi@gmail.com 10031947532846006733 10031947532846006733 No Department of Dermatology, Razi Hospital, Tehran University of Medical Sciences (TUMS), Tehran, Iran. Elham-Sadat Hosseini elham.s.hosseimi@yahoo.com 10031947532846006734 10031947532846006734 No Tehran University of Medical Sciences (TUMS), Tehran, Iran Arghavan Azizpour a63a@yahoo.com 10031947532846006735 10031947532846006735 Yes Department of Dermatology, Razi Hospital, Tehran University of Medical Sciences (TUMS), Tehran, Iran.