Caspian Journal of Internal Medicine

en Association of metformin and aspirin intake with mammographic breast density: a cross-sectional study Oncology Oncology Original Article Original Article Background: Our purpose was to investigate the association between Mammographic breast density (MBD), a known strong marker for breast cancer and metformin and aspirin use and duration of use alone or simultaneously, in a sample of Iranian women considering other confounding factors. Methods: In a cross-sectional study, 712 individuals were selected out of women referred to two university hospitals for screening mammography. Participants’ information was collected with a questionnaire. Four-category density scale (a = almost entirely fatty, b = scattered fibroglandular densities, c= heterogeneously dense, and d = extremely dense) was categorized as low (a&b) and high (c&d) density. Results: The mean age of the participants was 49.80 ± 7.26 years. Sixty-five percent of women belonged to the high and 35% to the low MBD category. Both aspirin and metformin had a significantly negative association with MBD, however, when confounding factors were entered into the models, only aspirin after adjustment for age and BMI had an inverse association with MBD (OR = 0.53, 95% CI: 0.35-0.94). Simultaneous use of metformin and aspirin (OR = 0.44, 95 %CI: 0.17-1.12) was associated with lower MBD. Furthermore, in women who used metformin (OR = 0.23, 95% CI: 0.09-0.62) and aspirin (O R= 0.35, 95% CI: 0.17-0.72) for 2 to 5 years, MBD was significantly lower. However, after the adjustment of confounding factors, these associations were not statistically significant. Conclusion: It seems metformin and aspirin intakes are associated with MBD. However, further studies with more sample size are needed.   Aspirin, Metformin, Mammographic Breast density, Risk factor. 741 745 http://caspjim.com/browse.php?a_code=A-10-2869-1&slc_lang=en&sid=1 Bita Eslami dr.bes.96@gmail.com 100319475328460044972 100319475328460044972 No Breast Diseases Research Center, Cancer Institute, Tehran University of Medical Science, Tehran, Iran Ramesh Omranipour omranipour@sina.tums.ac.ir 100319475328460044973 100319475328460044973 No Breast Diseases Research Center, Cancer Institute, Tehran University of Medical Science, Tehran, Iran Arvin Aryan arvinaryan@yahoo.com 100319475328460044974 100319475328460044974 No Department of Radiology, Advanced Diagnostic and Interventional Radiology Research Center, Imam Khomeini Hospital, Tehran University of Medical Sciences, Tehran, Iran Leila Bayani leilabayani@yahoo.com 100319475328460044975 100319475328460044975 No Department of Radiology, Arash Women’s Hospital, Tehran University of Medical Sciences, Tehran, Iran Mahboubeh Abedi abedi.mahboobeh@yahoo.com 100319475328460044976 100319475328460044976 No Department of Radiology, Arash Women’s Hospital, Tehran University of Medical Sciences, Tehran, Iran Sadaf Alipour sadafalipour@yahoo.com 100319475328460044977 100319475328460044977 Yes Breast Diseases Research Center, Cancer Institute, Tehran University of Medical Science, Tehran, Iran