en Neurology Neurology Original Article Original Article <p><span style="font-size:14px;"><span style="font-family:Times New Roman;"><span style="line-height:14pt"><b><i><span style="color:blue">Background</span></i></b><i><span style="color:blue">:</span></i> Stroke is one of the leading causes of mortality and morbidity worldwide accounting for 85% of global deaths from stroke. This study aimed to evaluate the role of homocysteine (HCY) in modulating various stroke parameters and its with carotid intima-media thickness (IMT).</span><br> <span style="line-height:14pt"><b><i><span style="color:blue">Methods:</span></i></b> 78 patients of radiology-confirmed acute ischemic stroke were recruited for this study and National Institutes of Health Stroke Scale (NIHSS) score was evaluated upon admission. Blood samples were tested for serum HCY, fasting blood glucose (FBG) and lipid profile. Ultrasonography of neck ascertained IMT of Common (CCA) and Internal carotid artery (ICA).</span><br> <span style="line-height:14pt"><b><i><span style="color:blue">Results:</span></i></b> Average age of male and female subjects was 57.88 &plusmn; 13.97 & 59.16 &plusmn; 13.62 years respectively. 71.93% of stroke patients were hyperhomocysteinemic (HHcyc) and 24.36% were hyperlipidemic. Patients with NIHSS &ge; 5 had higher low-density lipoprotein cholesterol (LDLC) than those with NIHSS < 5. HCY cutoff of &ge; 15 &mu;mol/L had 91.7% sensitivity & 66.7% specificity for predicting. HHcyc state was associated with increased ICA IMT. HHcyc state was best predicted by ICA IMT with which it is positively <span style="color:black">correlated (P-Value = 0.012).</span><span style="font-size:10.0pt"></span></span><br> <span style="line-height:14pt"><b><i><span style="color:blue">Conclusion</span></i></b><i><span style="color:blue">:</span></i> HHcyc state holds a good predictive value for severity of stroke. We also came to a conclusion that ICA IMT measurement may also reduce the need for a homocysteine test as it predicts higher HCY levels; this will reduce the burden on resources. We suggest that evaluating HCY and ICA IMT should be made part of the standard protocol for management of stroke.<span style="font-size:10.0pt"></span></span></span></span><br> &nbsp;</p> Homocysteine, Carotid Intima-Media Thickness, Stroke, CVA 259 265 http://caspjim.com/browse.php?a_code=A-10-400-3&slc_lang=en&sid=1 Vatsal Navin Jain jain.vatsaljain.vatsal@gmail.com 100319475328460053481 100319475328460053481 No Rajiv Gandhi Medical College & Chhatrapati Shivaji Maharaj Hospital, Kalwa, Thane, India Priyanka Rana priyankaranaa24@gmail.com 100319475328460053482 100319475328460053482 No Department of Biochemistry, Rajiv Gandhi Medical College & Chhatrapati Shivaji Maharaj Hospital, Kalwa, Thane, India Kshitij Arun Bhoge kshitij12bhoge@gmail.com 100319475328460053483 100319475328460053483 No Rajiv Gandhi Medical College & Chhatrapati Shivaji Maharaj Hospital, Kalwa, Thane, India Swati Ghanghurde 100319475328460053484 100319475328460053484 No Department of Pathology, Rajiv Gandhi Medical College & Chhatrapati Shivaji Maharaj Hospital, Kalwa, Thane, India Mahesh B Phad 100319475328460053485 0009-0004-3312-6838 No Department of Biochemistry, Government Medical College, Baramati, India Mohit Vijay Rojekar drmohi44@gmail.com 100319475328460053486 100319475328460053486 Yes Department of Biochemistry, Rajiv Gandhi Medical College & Chhatrapati Shivaji Maharaj Hospital, Kalwa, Thane, India