en Gastroentrology Gastroentrology Original Article Original Article <p align="left"> <font face="Times New Roman" size="3"> </font><font face="Times New Roman"><b><i><span lang="EN-US" style="color: blue font-size: 10pt">Background: </span></i></b><span lang="EN-US" style="font-size: 10pt">Although some patients can tolerate colonoscopy procedure using fentanyl/ midazolam without any sedation and analgesic requirements but some patients may require additional sedation with benzodiazepines. We performed the present study to compare the effect of paracetamol/midazolam with fentanyl/ midazolam.<b><i><span style="color: blue"><o:p /></span></i></b></span></font></p><p align="left"><font face="Times New Roman" size="3"> </font><font face="Times New Roman"><b><i><span lang="EN-US" style="color: blue font-size: 10pt">Methods:</span></i></b><span lang="EN-US" style="font-size: 10pt"> In a clinical trial, 96 patients aged 18 to 75 years old, who were candidate for elective colonoscopy assigned consecutively into two groups as paracetamol/midazolam and fentanyl/midazolam. The first group received 1 gr paracetamol 45 minutes before colonoscopy and 0.5 mg/kg midazolam 5 minutes before colonoscopy whereas the second group received 04- 0.5-1 mcg/kg fentanyl 3 minutes before colonoscopy and similar dose of midazolam. The two groups were compared in regard to patient intensity, discomfort, a colonoscopist and, patient </span><span class="hps"><span lang="EN-US" style="font-size: 10pt mso-fareast-font-family: "2 Nazanin"">satisfaction</span></span><span lang="EN-US" style="font-size: 10pt"> and rescue<font size="2"><span style="color: rgb(192, 0, 0)"> </span>dose of propofol during colonoscopy and vital signs.<span class="longtext"><span style="background: white color: black"><o:p /></span></span></font></span></font></p><p align="left"><font face="Times New Roman" size="3"> </font><font face="Times New Roman"><b><i><span lang="EN-US" style="color: blue font-size: 10pt">Results:</span></i></b><span lang="EN-US" style="font-size: 10pt"> There was no significant difference between the two groups for patient pain score, colonoscopist </span><span class="hps"><span lang="EN-US" style="font-size: 10pt mso-fareast-font-family: "2 Nazanin"">satisfaction</span></span><span lang="EN-US" style="font-size: 10pt">, patient </span><span class="hps"><span lang="EN-US" style="font-size: 10pt mso-fareast-font-family: "2 Nazanin"">satisfaction</span></span><span lang="EN-US" style="font-size: 10pt"> and rescue dose of<font size="2"><span style="color: rgb(192, 0, 0)"> </span>propofol (P=0.817, 0.978, 0.460, and 0.104, respectively). The incidence of apnea was greater in fentanyl group (P=0.045). After adjusting for age and education, there was also no significant difference between the two groups.<span class="longtext"><span style="background: white color: black"><o:p /></span></span></font></span></font></p><p align="left"><font face="Times New Roman" size="3"> </font><font face="Times New Roman"><b><i><span lang="EN-US" style="color: blue font-size: 10pt">Conclusion: </span></i></b><span lang="EN-US" style="font-size: 10pt">This study indicates that paracetamol can be considered as an alternative drug regimen in preparation of colonoscopy.<o:p /></span></font></p><p align="left"><font face="Times New Roman" size="3"> </font></p> Paracetamol, Fentanyl, Colonoscopy, Analgesia 87 92 http://caspjim.com/browse.php?a_code=A-10-237-1&slc_lang=en&sid=1 Abbasali Ahmadi 10031947532846002997 10031947532846002997 No Parviz Amri pamrimaleh@yahoo.com 10031947532846002998 10031947532846002998 Yes Javad Shokri-Shirvani 10031947532846002999 10031947532846002999 No Karimollah Hajian 10031947532846003000 10031947532846003000 No