en Nephrology Nephrology Original Article Original Article <span style="font-size:14px;"><span style="font-family:Times New Roman;"><span style="line-height:14pt"><b><i><span style="color:blue">Background</span></i></b><i><span style="color:blue">:</span></i> <span lang="EN">The unique role of eosinophil in coronavirus disease 2019 (COVID-19) patients has been shown in several studies, but its role in end-stage kidney disease (ESKD) patients who contracted COVID-19 is less reported. This study investigated eosinopenia&#39;s predictive value as a mortality marker in ESKD patients with COVID-19.</span></span><br> <span style="line-height:14pt"><b><i><span style="color:blue">Methods:</span></i></b> <span lang="EN">It is a retrospective study of ESKD patients who contracted COVID-19 between May 2020 and October 2021 in West Nusa Tenggara General Hospital, Indonesia. Comparative analysis was carried out between the death dan survival group. Logistic regression analysis was done to investigate the role of eosinopenia on the outcome after controlling other significant variables.</span><span style="font-size:10.0pt"></span></span><br> <span style="line-height:14pt"><b><i><span style="color:blue">Results:</span></i></b> <span lang="EN">The analyses included one hundred fifteen confirmed COVID-19 in ESKD patients. The average age was 50, 53% of patients were males, 41% were newly diagnosed with ESKD, and the mortality rate was 25.2%. This study&#39;s prevalence of eosinopenia, high neutrophil-to-lymphocyte ratio (NLR), and high C-reactive protein (CRP) in the nonsurvivors was 51.4%, 39.3%, and 30.8%, respectively. Diastolic blood pressure <90 mmHg (P=0.004), respiratory rate >22 x/minutes (P=0.011), oxygen saturation <93% (P=0.008), NLR >6 (p<0.001), eosinophil count <0.01 x10³/uL (p<0.001), CRP >20 mg/L (P=0.047), and isolation hemodialysis (HD) therapy (p<0.001) were independently associated with mortality of COVID-19 in ESKD patients. However, on multivariate logistic regression analysis, eosinopenia (P=0.019) and HD (P=0.001) were risk factors that remained significant prognostic mortality factors.</span></span><br> <span style="line-height:14pt"><b><i><span style="color:blue">Conclusion</span></i></b><i><span style="color:blue">:</span></i> <span lang="EN">Eosinopenia was common in ESKD patients with COVID-19, particularly in the death group. Eosinopenia at admission and HD during hospitalization were risk factors for COVID-19 mortality in ESKD patients.</span><span lang="DE-CH" style="font-size:10.0pt"></span></span></span></span><br> &nbsp; COVID-19, Eosinophil, ESKD, Hemodialysis, Mortality. 273 279 http://caspjim.com/browse.php?a_code=A-10-2219-2&slc_lang=en&sid=1 Asmara I Gede Yasa yasa.asmara@unram.ac.id 100319475328460049731 100319475328460049731 Yes Department of Internal Medicine, Faculty of Medicine, University of Mataram - West Nusa Tenggara General Hospital, Mataram, Indonesia Agustriadi I Gusti Ngurah Ommy ommy_agustriadi@yahoo.com.sg 100319475328460049732 100319475328460049732 No Department of Internal Medicine, Faculty of Medicine, University of Mataram - West Nusa Tenggara General Hospital, Mataram, Indonesia Sujaya I Made sujayamade68@gmail.com 100319475328460049733 100319475328460049733 No Department of Internal Medicine, Faculty of Medicine, University of Mataram - West Nusa Tenggara General Hospital, Mataram, Indonesia Thalib Salim Said salimthalib2@gmail.com 100319475328460049734 100319475328460049734 No Department of Internal Medicine, Faculty of Medicine, University of Mataram - West Nusa Tenggara General Hospital, Mataram, Indonesia Lestari Rina drrinalestari@gmail.com 100319475328460049735 100319475328460049735 No Department of Pulmonology, Faculty of Medicine, University of Mataram - West Nusa Tenggara General Hospital, Mataram, Indonesia Fatrullah Suryani Padua sury_padua@yahoo.co.id 100319475328460049736 100319475328460049736 No Department of Pulmonology, Faculty of Medicine, University of Mataram - West Nusa Tenggara General Hospital, Mataram, Indonesia Widiasari Komang Sri Rahayu widia.hayu@gmail.com 100319475328460049737 100319475328460049737 No Department of Pulmonology, Faculty of Medicine, University of Mataram - West Nusa Tenggara General Hospital, Mataram, Indonesia Ajmala Indana Eva indanaeva@gmail.com 100319475328460049738 100319475328460049738 No Department of Pulmonology, Faculty of Medicine, University of Mataram - West Nusa Tenggara General Hospital, Mataram, Indonesia