en Gastroentrology Gastroentrology Original Article Original Article <span style="font-size:14px;"><span style="font-family:Times New Roman;"><span style="line-height:14pt"><b><i><span style="color:blue">Background</span></i></b><i><span style="color:blue">:</span></i> There are few <span style="color:black">reports evaluating different factors, including the severity of duodenal histopathological findings and serological levels of celiac disease (CD), in increasing the probability of thyroid diseases (TD) in adults and children with CD, so, we designed this research. </span></span><br> <span style="line-height:14pt"><b><i><span style="color:blue">Methods:</span></i></b><span style="color:black"> CD was defined as Marsh type 2 or higher in duodenal histopathology and serological levels of anti-transglutaminase antibodies (anti-tTG) equal to or greater than 18 IU/ml. To assess the likelihood of TD in CD patients, logistic regression analysis was employed.</span></span><br> <span style="line-height:14pt"><b><i><span style="color:blue">Results:</span></i></b><span style="color:black"> 538 patients were included in this study. Of these, 354 (65.8%) were females and 184 (34.2%) were males. 370 (68.8%) patients were children. Overall, 57 (10.6%) patients had TD, of which 49 (9.1%) had hypothyroidism and 8 (1.5%) had hyperthyroidism. Adults had a significantly higher probability of developing TD than children (OR 1.9; 95% CI 1.1-3.4; P = 0.03). The odds of developing TD were also significantly higher in patients with</span> <span style="color:black">family marriage in parents (OR 2.3; 95% CI 1.1-4.7; P = 0.03). Other variables such as gastrointestinal symptoms, anti-tTG levels, and severity of Marsh classification did not exhibit a substantial rise in the likelihood of TD development.</span></span><br> <span style="line-height:14pt"><b><i><span style="color:blue">Conclusion</span></i></b><i><span style="color:blue">:</span></i> <span style="color:black">The study findings indicated that the likelihood of developing TD </span>in CD patients can be linked to advancing age and having family marriage in parents, while there was no significant association observed with anti-tTG levels, severity of histological damage, and gastrointestinal symptoms.</span></span></span><br> &nbsp; Thyroid disease, Celiac disease, Children, Adults, Serology, Histology. 307 312 http://caspjim.com/browse.php?a_code=A-10-1157-2&slc_lang=en&sid=1 Ramin Niknam niknamramin@yahoo.com 100319475328460047759 100319475328460047759 No Gastroenterohepatology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran Heydar Baseri Heydar.baseri@yahoo.com 100319475328460047760 100319475328460047760 No Gastroenterohepatology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran Laleh Mahmoudi mahmoudi_l@sums.ac.ir 100319475328460047761 100319475328460047761 No Department of Clinical Pharmacy, School of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran Mohammad Reza Fattahi fattahim38@yahoo.com 100319475328460047762 100319475328460047762 No Gastroenterohepatology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran Ebrahim Fallahzadeh Abarghooee ebrahimfz@yahoo.com 100319475328460047763 100319475328460047763 No Gastroenterohepatology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran Ali Zamani zamania@sums.ac.ir 100319475328460047764 100319475328460047764 Yes Endocrine and Metabolism Research Center, Shiraz University of Medical Sciences. Shiraz, Iran