en Pulmonology Pulmonology Original Article Original Article <p align="left"> <font face="Times New Roman" size="3"> </font><font face="Times New Roman"><b><i><span lang="EN-US" style="color: blue font-size: 10pt">Background: </span></i></b><span lang="EN-US" style="font-size: 10pt">Vitamin D has a potential to modulate inflammatory response against noxious particles in patients with chronic obstructive pulmonary disease (COPD). The present study was conducted to determine the status of serum vitamin D in COPD versus healthy group.<b><i><span style="color: blue"><o:p /></span></i></b></span></font></p><p align="left"><font face="Times New Roman" size="3"> </font><font face="Times New Roman"><b><i><span lang="EN-US" style="color: blue font-size: 10pt">Methods:</span></i></b><span lang="EN-US" style="font-size: 10pt"> The patients presented to the outpatient pulmonary clinic of Ayatollah Rouhani Hospital, Babol Iran. Diagnosis of COPD was confirmed based on airflow limitation defined as FEV1/FVC ratio <70% and FEV1< 80% of predicted. All eligible patients aged ≥ 40 years old entered the study. Pulmonary infection, tuberculosis, pleural effusion, congestive heart failure, pulmonary hypertension and embolism, restrictive airway disease, conditions leading changes in vitamin D metabolism and absorption were excluded. Serum 25-hydroxyvitamin D (25-OHD) was determined by electrocheminluminescence method and levels <20, 20-29, and ≥30ng/ml were considered as deficiency, insufficiency, and sufficiency. In statistical analysis, the frequency of serum 25-OHD deficiency and insufficiency in patients were compared regarding age of ≤ 50 or >50 years old. All patients were males and age and sex-matched controls were selected among healthy subjects accompanied COPD patients.<span class="longtext"><span style="background: white"><o:p /></span></span></span></font></p><p align="left"><font face="Times New Roman" size="3"> </font><font face="Times New Roman"><b><i><span lang="EN-US" style="color: blue font-size: 10pt">Results:</span></i></b><span lang="EN-US" style="font-size: 10pt"> Ninety patients and 100 controls with respective mean (±SD) age of 64.8±11.7 and 62.6±11.7 years old (P=0.19) were studied. Compared with control, proportions of serum 25-OHD deficiency and insufficiency in patients >50 years were higher and deficiency was lower (61.5% vs 87.5%, P=0.11).<span class="longtext"><span style="background: white color: black"><o:p /></span></span></span></font></p><p align="left"><font face="Times New Roman" size="3"> </font><font face="Times New Roman"><b><i><span lang="EN-US" style="color: blue font-size: 10pt">Conclusion: </span></i></b><span lang="EN-US" style="font-size: 10pt">These findings indicate that a significant proportion of young COPD patients have insufficient serum 25-OHD. Regarding a positive relationship between 25-OHD and FEV1 in COPD, these findings highlight serum 25-OHD assessment in COPD for recognizing high risk patients.<o:p /></span></font></p><p align="left"><font face="Times New Roman" size="3"> </font></p> vitamin D, COPD, Deficiency, insufficiency 93 97 http://caspjim.com/browse.php?a_code=A-10-182-1&slc_lang=en&sid=1 Behzad Heidari heidarib14@yahoo.com 10031947532846002984 10031947532846002984 No mobility impairment research center Yahya Javadian javad835@yahoo.com 10031947532846002985 10031947532846002985 Yes mobility impairment research center Mahmoud Monadi monadim@yahoo.com 10031947532846002986 10031947532846002986 No Department of Internal Medicine, Rouhani Hospital, Babol University of Medical Sciences, Babol, Iran. Yahya Dankoub dankouy@yahoo.com 10031947532846002987 10031947532846002987 No Department of Internal Medicine, Rouhani Hospital, Babol University of Medical Sciences, Babol, Iran. Alireza Firouzjahi firouzjahia@yahoo.com 10031947532846002988 10031947532846002988 No Department of Laboratory Medicine, Ayatollah Rouhani Hospital, Babol University of Medical Sciences, Babol, Iran