en Infectious Diseases Infectious Diseases Review Article Review Article <p><span style="font-family: times new roman;"><span style="color: rgb(0, 0, 255);"><strong><em>Background: </em></strong></span>Human toxoplasmosis is an important zoonotic infection worldwide which is caused by the intracellular parasite <em>Toxoplasma gondii </em>(T.gondii). The aim of this study was to review briefly the general aspects of toxoplasma infection in&nbsp;&nbsp; in Iranian health system network.</span></p> <p><span style="font-family: times new roman;"><span style="color: rgb(0, 0, 255);"><strong><em>Methods:</em></strong></span> We searched published toxoplasmosis related articles in English databases including Science Direct, Pub Med, Scopus, Google Scholar, Magiran, Iran Medex, Iran Doc and Scientific Information Database (SID) for toxoplasmosis.</span></p> <p><span style="font-family: times new roman;"><span style="color: rgb(0, 0, 255);"><strong><em>Results:</em></strong></span> Out of 1267 articles from the English and Persian databases search, 40 articles were suitable with our research objectives and so were selected for the study.&nbsp; It is estimated that at least a third of the world human population is infected with T.gondii, suggesting it as one of the most common parasitic infections through the world.&nbsp; Maternal infection during pregnancy may affect dangerous outcome for the fetus, or even cause intrauterine death. Reactivation of a previous infection in immunocompromised patient such as drug induced, AIDS and organ transplantation can cause life-threating central nervous system infection. Ocular toxoplasmosis is one of the most important causes of blindness, especially in individuals with a deficient immune system.</span></p> <p><span style="font-family: times new roman;"><span style="color: rgb(0, 0, 255);"><strong><em>Conclusion: </em></strong></span>According to the increasing burden of toxoplasmosis on human health, the findings of this study highlight the appropriate preventive measures, diagnosis, and management of this disease.</span></p> Toxoplasma infection, T. gondii, Epidemiology, Health center, Iran 233 241 http://caspjim.com/browse.php?a_code=A-10-28-7&slc_lang=en&sid=1 Seyedmohammad Alavi alavi.seyedmohammad@yahoo.com 10031947532846007156 10031947532846007156 No Health Research Institute, Infections and Tropical Diseases Research Center, Jundishapur University of Medical Sciences,Ahvaz, Iran Leila Alavi leila.alavi 87@yahoo.com 10031947532846007157 10031947532846007157 Yes Food and Drug Deputy, Jundishapur University of Medical Sciences,Ahvaz, Iran