Caspian Journal of Internal Medicine
1
Caspian J Intern Med
Medical Sciences
http://caspjim.com
1
admin
2008-6164
2008-6172
8
10.22088/cjim
14
8888
13
en
jalali
1393
10
1
gregorian
2015
1
1
6
1
online
1
fulltext
en
Minimal inhibitory concentration of microorganisms causing surgical site infection in referral hospitals in North of Iran, 2011-2012
Internal
Internal
Short Communication
Short Communication
Abstract
Background: A surgical site infection (SSI) is the most common nosocomial infection after surgery and is the third most common infection in hospitalized patients. The aim of this study was to asses minimum inhibitory concentration (MIC) of the causing agents of SSI and antimicrobial susceptibility patterns.
Methods: This cross-sectional study was done in three referral hospitals in North of Iran during 2011-2012. The samples were taken one month after orthopedic, abdominal, cesarean section surgery and coronary artery bypass graft (CABG) in patients with scores compatible to SSIs criteria. The sample was sent for bacteriologic culture and MIC determination for positive cases by broth microdilution method. The data were collected and analyzed.
Results: From 103 positive cases S. aureus, E.coli and coagulase negative staphylococci were the most common isolated agents as 29.12%, 23.3% and 21.3%, respectively. S. aureus was sensitive to vancomycin (70%), amikacin (70%) and teicoplanin (76.6%) and cogulase negative staphylococci was sensitive to vancomycin (68.1%) and teicoplanin (72.6%) and E.coli to amikacin (95.83%) and imipenem and meropenem (66.66%). P.aeroginosa showed no sensitivity to cefepime and was sensitive to imipenem (93.75%) and meropenem (81.25%).
Conclusion: The most important point is worrisome problem of the increased MIC of S. aureus to vancomycin that causes difficult use in the treatment of staphylococcal SSIs. In spite of resistance of micro-organisms to cephalosporins, gram negative organisms had low MIC to carbapenemes especially P.aeroginosa although the rate of its MIC is increasing.
Minimal Inhibitory Concentration, Surgical site infection, Resistance, Antibiotics
34
39
http://caspjim.com/browse.php?a_code=A-10-1-16&slc_lang=en&sid=1
Ahmad
Alikhani
10031947532846002612
10031947532846002612
No
Department of Antimicrobial Resistance Research Center, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran.
Farhang
Babamahmoodi
10031947532846002613
10031947532846002613
Yes
Department of Antimicrobial Resistance Research Center, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran.
Laleh
Foroutan Alizadegan
10031947532846002614
10031947532846002614
No
Mazandaran University of Medical Sciences, Sari, Iran.
Arman
Shojaeefar
10031947532846002615
10031947532846002615
No
Ghaemshahr Razi Hospital, Ghaemshahr, Iran
Abdolreza
Babamahmoodi
10031947532846002616
10031947532846002616
No
Health Management Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran