Caspian Journal of Internal Medicine
1
Caspian J Intern Med
Medical Sciences
http://caspjim.com
1
admin
2008-6164
2008-6172
8
10.22088/cjim
14
8888
13
en
jalali
1393
10
1
gregorian
2015
1
1
6
1
online
1
fulltext
en
مقایسه اثر آرامبخشی اتومیدیت –فنتانیل و پروپوفول – فنتانیل در بیماران کاندید کولونوسکوپی :یک مطالعه تصادفی آینده نگر
Sedation with etomidate-fentanyl versus propofol-fentanyl in colonoscopies: A prospective randomized study
Infectious Diseases
Infectious Diseases
Original Article
Original Article
Abstract
Background: The combination of propofol-fentanyl for sedation during colonoscopy is characterized by the frequent incidence of side effects. Etomidate-fentanyl provides fewer hemodynamic and respiratory complications. The aim of our study was to compare the safety and efficacy of propofol-fentanyl and etomidate-fentanyl for conscious sedation in elective colonoscopy.
Methods: This double-blind clinical trial was conducted on 90 patients aged between 18 and 55 years old who were candidates for elective colonoscopy. Patients were randomized to receive sedation with fentanyl plus propofol or etomidate. Two minutes after injecting 1 micro/kg of fentanyl, the patients received propofol (0.5 mg/kg followed 25 micro/kg/min) or etomidate (0.1 mg/kg followed 15 micro/kg/min). Pulse rate, mean arterial blood pressure, respiratory rate, and saturation of peripheral oxygen (SPO2) were monitored. Indeed, the patient and colonoscopist satisfaction, the recovery time, sedation and pain score in both groups were assessed.
Results: Sedation score in propofol group was higher. Pain score as well as the physician and patient satisfaction showed no significant difference in two study groups. Hemodynamic changes and arterial saturation were the same in both groups. The duration of recovery was 1.27±0.82 minutes in the etomidate group whereas, it was 2.57±2.46 minutes in the propofol group (P=0.001). Hospital discharge in the propofol group was 5.53±4.67 minutes and in the etomidate group was 2.68±3.14 minutes (p=0.001).
Conclusion: The combination of fentanyl and etomidate provides an acceptable alternative to sedation with fentanyl and propofol with the advantage of significantly faster recovery time, which are of relevance in the outpatient setting.
propofol, etomidate, colonoscopy, sedation
15
19
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Nadia
Banihashem
نادیا
بنی هاشم
nbanihashem@yahoo.com
10031947532846002775
10031947532846002775
No
Babol University of Medical Sciences
دانشگاه علوم پزشکی بابل
Ebrahim
Alijanpour
ابراهیم
علیجانپور
dralijanpour@yahoo.com
10031947532846002776
10031947532846002776
No
Babol University of Medical Sciences
دانشگاه علوم پزشکی بابل
Majid
Basirat
مجید
بصیرت
10031947532846002777
10031947532846002777
No
Babol University of Medical Sciences
دانشگاه علوم پزشکی بابل
Javad
Shokri
جواد
شکری
10031947532846002778
10031947532846002778
No
Babol University of Medical Sciences
دانشگاه علوم پزشکی بابل
Mehrdad
Kashifard
مهرداد
کاشی فرد
10031947532846002779
10031947532846002779
No
Babol University of Medical Sciences
دانشگاه علوم پزشکی بابل
Seyed Hasan
Taheri
سید حسن
طاهری
10031947532846002780
10031947532846002780
No
Babol University of Medical Sciences
دانشگاه علوم پزشکی بابل
Shahryar
Savadkohi
شهریار
سوادکوهی
10031947532846002781
10031947532846002781
No
Babol University of Medical Sciences
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Vahid
Hosseini
وحید
حسینی
dr.vahid47@gmail.com
10031947532846002782
10031947532846002782
Yes
Mazandaran University of Medical Sciences
دانشگاه علوم پزشکی مازندران
seyed sedigheh
solimanian
سید صدیقه
سلیمانیان
ans_dep@yahoo.com
10031947532846002783
10031947532846002783
No
Babol University of Medical Sciences
دانشگاه علوم پزشکی بابل