Caspian Journal of Internal Medicine
1
Caspian J Intern Med
Medical Sciences
http://caspjim.com
1
admin
2008-6164
2008-6172
8
10.22088/cjim
14
8888
13
en
jalali
1395
4
1
gregorian
2016
7
1
7
3
online
1
fulltext
en
Evaluation of soluble human leukocyte antigen-G in pripheral blood of pregnant women with gestational diabetes melitus
Obstetrics & Gynicology
Obstetrics & Gynicology
Original Article
Original Article
<p style="margin-left: 161.6pt;"><span style="font-family: times new roman;"><span style="color: rgb(0, 0, 255);"><strong><em>Background: </em></strong></span>Research says that diabetes may develop in over 10% of non-diabetic pregnant women. Diabetes which generally occurs late in second trimester and third trimester of pregnancy, it is called gestational diabetes. Overweight or suffering from obesity before pregnancy is type 2 diabetes risk factor. In most cases, diabetic symptoms disappear after delivery. HLA-G has an important role both in mother and fetus tolerance during pregnancy, it may also be effective in the protection of pancreatic islet cells. In this study, concentration of these molecules in pregnant women with gestational diabetes in comparison with normal pregnant women was investigated.</span></p>
<p style="margin-left: 161.6pt;"><span style="font-family: times new roman;"><span style="color: rgb(0, 0, 255);"><strong><em>Methods:</em></strong></span> In this case-control study, we measured serum HLA-G levels in 24 pregnant women with gestational diabetes compared with 30 normal pregnant women using sandwich ELISA.</span></p>
<p style="margin-left: 161.6pt;"><span style="font-family: times new roman;"><span style="color: rgb(0, 0, 255);"><strong><em>Results:</em></strong></span> HLA-G levels were significantly low in pregnant women with gestational diabetes in contrast to normal pregnant women (P=0.001).</span></p>
<p style="margin-left: 161.6pt;"><span style="font-family: times new roman;"><span style="color: rgb(0, 0, 255);"><strong><em>Conclusion: </em></strong></span>In this study, we found that HLA-G levels were reduced in women with gestational diabetes compared with control group. Therefore, it is suggested that measurement of HLA-G in pregnant women can be considered as an indicator in prognosis of gestational diabetes.</span></p>
HLA-G, gestational diabetes, pregnancy
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182
http://caspjim.com/browse.php?a_code=A-10-391-1&slc_lang=en&sid=1
Saeide-Sadat
Shobeiri
setare@yahoo.com
10031947532846005963
10031947532846005963
No
Department of Immunology , Immunogenetic Research Center, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran.
Saeid
Abediankenari
abedianlab@yahoo.co.uk
10031947532846005964
10031947532846005964
Yes
Immunogetics Research Center , Mazandaran University of Medical Sciences, Sari, Iran
Bahareh
Lashtoo aghaee
bahareh@yahoo.com
10031947532846005965
10031947532846005965
No
Department of Microbiology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
Zahra
Rahmani
rahmani@yahoo.com
10031947532846005966
10031947532846005966
No
Immunogenetics Research Center, Mazandaran University of Medical Sciences, sari, Iran.
Bahareh
Esmaeili-Gorji
bBatool@yahoo.com
10031947532846005967
10031947532846005967
No
Department of Biology, Qaemshahr branch, Islamic Azad University, Qaemshahr, Iran.