Caspian Journal of Internal Medicine
1
Caspian J Intern Med
Medical Sciences
http://caspjim.com
1
admin
2008-6164
2008-6172
8
10.22088/cjim
14
8888
13
en
jalali
1397
2
1
gregorian
2018
5
1
9
3
online
1
fulltext
en
Reparative radiological changes of hip joint after TNF inhibitors in ankylosing spondylitis
Reumatology
Reumatology
Short Communication
Short Communication
<p style="line-height: 115%; text-indent: 0cm; margin-top: 0cm; margin-right: 0cm; margin-bottom: 0pt;"><span style="font-size: 14px;"><font face="Times New Roman"><b><i><span style="color: blue; line-height: 115%;">Background:</span></i></b><font color="#000000"><b><span style="line-height: 115%;"> </span></b><span style="line-height: 115%;">Hip involvement in ankylosing spondylitis (AS) is a common extraspinal arthritic manifestation, which is associated to a worse functional outcome. Little data are available on the effectiveness of conservative treatment strategies. The TNF inhibitors have been proven effective on AS activity parameters. Their structural effect on hip disease however, little is studied. </span></font></font></span></p>
<p style="line-height: 115%; text-indent: 0cm; margin-top: 0cm; margin-right: 0cm; margin-bottom: 0pt;"><span style="font-size: 14px;"><font face="Times New Roman"><b><i><span style="color: blue; line-height: 115%;">Case presentation:</span></i></b><span style="line-height: 115%;"><font color="#000000"> We describe four new cases of reparative changes of a damaged hip joint after treatment with TNF inhibitors. The average of age was 32.5 (27- 36) years. There were 3 men and 1 woman. Hip involvement was bilateral in all cases. Etanercept was prescribed in 3 cases and infliximab in 1 case. At baseline, all patients had a painful and limited hip with high disease activity and an important functional impairment. After an average of 5.5 years of treatment with TNF inhibitors, the BASRI hip evaluated in antero-posterior x-rays of the pelvis remained unchanged at 2.4. The average of mean hip joint space was 2.9mm (2.3-3.6). A widening in hip joint space was observed in all cases with less subchondral cysts.</font></span></font></span></p>
<p style="line-height: 115%; text-indent: 0cm; margin-top: 0cm; margin-right: 0cm; margin-bottom: 0pt;"><span style="font-size: 14px;"><font face="Times New Roman"><b><i><span style="color: blue; line-height: 115%;">Conclusion:</span></i></b><font color="#000000"><span style="background: white; line-height: 115%;"> </span><span style="line-height: 115%;">TNF inhibitors seem to be effective on hip joint disease in patients with AS.</span></font></font></span></p>
spondylarthritis, hip, imaging, TNF inhibitors
303
305
http://caspjim.com/browse.php?a_code=A-10-534-1&slc_lang=en&sid=1
Kaouther
Maatallah
kaoutherm1986@yahoo.fr
100319475328460013099
100319475328460013099
No
Department of Rheumatology, Kassab Institut Manouba 2010, El Manar Tunis University, Tunisia
Ines
Mahmoud
nefmhd@yahoo.fr
100319475328460013100
100319475328460013100
Yes
Department of Rheumatology Charles Nicolle Hospital, 1006 Bab Souika, El Manar Tunis University, Tunisia
Safa
Belghali
safabel@yahoo.fr
100319475328460013101
100319475328460013101
No
Department of Rheumatology, Farhat Hached Hospital, 4002 Medina of Sousse, Sousse University, Tunisia
Kawther
Ben Abdelghani
Kaouther_ba@yahoo.fr
100319475328460013102
100319475328460013102
No
Department of Rheumatology, La Marsa Hospital, 2046 Sidi Daoud, El Manar, Tunis University, Tunisia
Olfa
Saidane
olfa-saidane@yahoo.fr
100319475328460013103
100319475328460013103
No
Department of Rheumatology Charles Nicolle Hospital, 1006 Bab Souika, El Manar Tunis University, Tunisia
Elyes
Bouajina
elyesbouajina@yahoo.fr
100319475328460013104
100319475328460013104
No
Department of Rheumatology, Farhat Hached Hospital, 4002 Medina of Sousse, Sousse University, Tunisia
Ahmed
Laatar
Laatarah@yahoo.fr
100319475328460013105
100319475328460013105
No
Department of Rheumatology, La Marsa Hospital, 2046 Sidi Daoud, El Manar, Tunis University, Tunisia
Rawdha
Tekaya
rawdharawdha@yahoo.fr
100319475328460013106
100319475328460013106
No
Department of Rheumatology Charles Nicolle Hospital, 1006 Bab Souika, El Manar Tunis University, Tunisia
Leila
Abdelmoula
leila_abdelmoula@yahoo.fr
100319475328460013107
100319475328460013107
No
Department of Rheumatology Charles Nicolle Hospital, 1006 Bab Souika, El Manar Tunis University, Tunisia