en
jalali
1389
10
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gregorian
2011
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2
online
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fulltext
en
Knee osteoarthritis prevalence, risk factors, pathogenesis and features: Part I
Osteoarthritis (OA) a common disease of aged population and one of the leading causes of disability. Incidence of knee OA is rising by increasing average age of general population. Age, weight, trauma to joint due to repetiting movements in particular squatting and kneeling are common risk factors of knee OA. Several factors including cytokines, leptin, and mechanical forces are pathogenic factors of knee OA. In patients with knee pain attribution of pain to knee OA should be considered with caution. Since a proportion of knee OA are asymptomatic and in a number of patients identification of knee OA is not possible due to low sensitivity of radiographic examination. In this review data presented in regard to prevalence, pathogenesis, risk factors.
Knee, Osteoarthritis, Pathogenesis, Prevalence
205
212
http://caspjim.com/browse.php?a_code=A-10-62-53&slc_lang=en&sid=1
2014/01/14
1392/10/24
2014/01/14
1392/10/24
Behzad
Heidari
003194753284600431
003194753284600431
Yes
en
Metabolic capacity of CYP2D6 within an Iranian population (Mazandaran Province)
Background: CYP2D6 is polymorphically expressed enzyme that show marked interindividual and interethnic variation. Phenotyping of CYP2D6 provides valuable information about real-time activity of this important drug-metabolizing enzymes through the use of specific probe drugs. The aim of this study was to identify the CYP2D6 oxidation phenotype with dextromethorphan (DEX) as a probe drug in Mazandarani ethnic group among Iranian population. Methods: The study included 71 unrelated healthy volunteers. Dextromethorphan hydrobromide (30 mg) was given orally to healthy subjects and peripheral venous blood samples (10 ml) were taken at 3 hr post-dose. Dextromethorphan and the metabolite dextrorphan (DOR) were analyzed by the HPLC method. The log DEX/DOR metabolic ratio (MR) at 3 hr plasma sample was used as the index of CYP2D6 activity and a value of 0.3 was used as the antimode separating extensive metabolizers (EM) and poor metabolizers (PM) phenotypes. Results: A 560-fold interindividual variation in dextromethorphan MRs was observed in this study. Considering the antimode 0.3 in log scale, 7.04% (5/71) volunteers were identified as PMs.Conclusion: The result showed that the frequency of CYP2D6 PM phenotypes accounted for 7.04% of subjects in our samples. Despite these findings, we propose a further study in larger samples to provide a wider image and to get more valuable information upon pharmacogenetic basis for individual therapy and personalized medicine.
Phenotype, Polymorphism, CYP2D6, Dextromethorphan, Mazandaran, Iran
213
217
http://caspjim.com/browse.php?a_code=A-10-62-45&slc_lang=en&sid=1
2014/01/142014/01/14
1392/10/24
2014/01/142014/01/14
1392/10/24
Shiran
Mohammad Reza
003194753284600393
003194753284600393
Yes
Fatemeh
Sarzare
003194753284600394
003194753284600394
No
Fatemeh
Merat
003194753284600395
003194753284600395
No
Ebrahim
Salehifar
003194753284600396
003194753284600396
No
Ali Akbar
Moghadamnia
003194753284600397
003194753284600397
No
Seyed Mohammad Bagher
Hashemi Soteh
003194753284600398
003194753284600398
No
en
Comparative study of levamisole-selenium supplementation effect on CD4 increase in HlV / AIDS patients
Background: Given to the abundant incidence of malnutrition in HIV+ patients and its effect on progress of AIDS disease, several studies have recommended supplementation therapy (such as Selenium, Levamisole, Zinc). Methods: This clinical trial was prefunded on patient's with HIV + in Behavior Diseases Consulting Center, Kermanshah, Iran 2006-2007. One hundred-seventy eight out of all patients with CD4 1ess than 350 cell/mm3 who did not receive antiretroviral drugs were in this study. They were divided into four groups: the first group received 200 micg selenium per day, the second group received levamisole 50 mg every other day, and third group received both two drugs. The fourth group was the control group. All four groups were studied for six months. Patients' baseline CD4 and other data were recorded in a form. CD4 was rechecked after six months and collected values were compared with basic values. CD4 changes were compared among all groups, either.Results: One hundred-seventy eight patients initiated treatment and 108 cooperated in the 6-month follow up assessment. Niuety-two (85%) were males and 15% were female. CD4 decreased in control group and Levamisole group during the study which was significant, but 13 units increase was seen in Selenium-Levamisole group. CD4 count decreased 36 units in Selenium group. Comparing CD4 count change among 4 study groups showed that only CD4 change between Selenium-Levamisole group and control group was significant. Conclusion: Regarding to collected results, Selenium-Levamisole supplementation can be used as a supplementation therapy besides antiretroviral therapies.
HIV, CD4, Levamisole, Selenium, Kermanshah
218
221
http://caspjim.com/browse.php?a_code=A-10-62-46&slc_lang=en&sid=1
2014/01/142014/01/142014/01/14
1392/10/24
2014/01/142014/01/142014/01/14
1392/10/24
Mansouri
Feizollah
003194753284600399
003194753284600399
Yes
Alireza
Janbakhsh
003194753284600400
003194753284600400
No
Siavash
Vaziri
003194753284600401
003194753284600401
No
Babak
Sayad
003194753284600402
003194753284600402
No
Mandana
Afsharian
003194753284600403
003194753284600403
No
Farzaneh
Hosseinpor
003194753284600404
003194753284600404
No
Behzad
Mahdavian
003194753284600405
003194753284600405
No
en
The relationship between helicobacter pylori infection and myocardial infarction
Background: Coronary Artery Disease is known as the main cause of death in industrialized countries. Relation between this disease and some infections such as Helicobacter pylori (H.pylori) has been shown in several studies. The purpose of this study was to dermine the relationship between Hypylori and mycardical infarctions. Methods: Seventy-three myocardial infarction patients and 78 individuals with no history of this disease were compared. Patients and control matched for age and sex person to person by the match method. Levels of serum IgA and IgG antibodies against H. pylori were measured by Elisa method. Also, cholesterol, triglyceride, LDL, HDL measured in both groups and data were compared between two groups in terms of relation with cardiac risk factors.Results: From 151 participants, 73 were patients and 78 were control subjects. The percentage of IgG positive cases against H. pylori was 57.5% in the case group and 32.1% in the control group (p=0.002, OR: 2.87 CI: 95% 1.5-5.6). Meanwhile, there was no significant difference in IgA positive cases between the two groups (42.5% and 48.7% in the case and control groups, respectively) (p=0.44 OR: 0.78 95% CI 0.41-1.48). The study showed 74.2% of cases in the case group and 45.2% in the control group were positive for both IgG and IgA (p=0.01 OR: 3.5 95% CI 1.3-9.5). No significant differences were found between two groups in terms of relation between H. pylori related antibodies level and heart disease classic risk factors (smoking, hypertension,…), sex, and age, but between dyslipidemia and H. pylori related antibodies was significant differences in case group (p=0.05). Conclusion: According to the results, it seems there is a relation between H. pylori infection and myocardial infarction. Also, between dislipidemia and H. Pylori antibodies in case group were significant difference. Therefore, H. pylori can be a new risk factor for atherosclerosis or can be exacerbate effect of other risk factors. Proper diagnosis and treatment of these infections can be useful in prone patients. More studies with larger sample groups are needed to review the possible role of this pathogen as a heart disease risk factor.
Helicobacter pylori, IgG, IgA, Myocardial infarction
222
225
http://caspjim.com/browse.php?a_code=A-10-62-52&slc_lang=en&sid=1
2014/01/142014/01/142014/01/142014/01/14
1392/10/24
2014/01/142014/01/142014/01/142014/01/14
1392/10/24
Zohreh
Azarkar
003194753284600428
003194753284600428
Yes
Majid
Jafarnejad
003194753284600429
003194753284600429
No
Gholamreza
Sharifzadeh
003194753284600430
003194753284600430
No
en
Serum interleukins 6 and 8 in mild and severe asthmatic patients, is it difference?
Background: About 5–10% of patients with asthma suffer from poorly-controlled disease despite corticosteroid (CS) therapy. Methods: 21 severe and 30 mild asthma patients were recruited and underwent collection of blood sample. We determined whether there were any differences in inflammatory biomarkers between severe and mild asthma patients or not.Results: Levels of Interleukin-8 (IL-8) and Interleukin-6 (IL-6) in blood supernatants were similar in both groups of asthma patients. Leukocytes were in range of normal in all patients. Increased eosinophil was in 29% of severe cases and 23% in mild cases. IgE level was increased in 43% of severe form and 50% in mild form.Conclusion: There is not any difference between severe and mild asthma in serum IL-8 and IL-6. Therefore, level of serum cytokines may not predict severity of asthma.
Severe asthma, Mild asthma, Interleukin 6, Interleukin8
226
228
http://caspjim.com/browse.php?a_code=A-10-62-47&slc_lang=en&sid=1
2014/01/142014/01/142014/01/142014/01/142014/01/14
1392/10/24
2014/01/142014/01/142014/01/142014/01/142014/01/14
1392/10/24
Javad
Ghaffari
003194753284600406
003194753284600406
Yes
Ali Reza
Rafiei
003194753284600407
003194753284600407
No
Abolghasem
Ajami
003194753284600408
003194753284600408
No
Mohammadreza
Mahdavi
003194753284600409
003194753284600409
No
Bahareh
Hoshiar
003194753284600410
003194753284600410
No
en
Hyperprolactinemia in association with subclinical hypothyroidism
Background: Hyperprolactinemia is the most common endocrine disorder in hypothalamic-pituitary axis and has been reported in variable levels in patients with overt primary hypothyroidism. We decided to determine the prevalence of hyperprolactinemia and clinical related symptoms in subclinical hypothyroidism patients. Methods: In this cross sectional study, prolactin levels of 481 subclinical hypothyroid patients were assessed. Prolactin measurement was performed using chemiluminescent immunoassay. Data were collected and analyzed.Results: Sixty-two (13%) patients were males and 419 (87%) were females. The mean age of the patients was 32.53±10.13 years. Ninty-eight patients (91 females 7 males) had high prolactin. Prevalence of hyperprolactinemia in subclinical hypothyroidism was 20.4%. (11% in men and 22% in women, p=0.05). There was no correlation between the serum TSH and prolactin level. Clinical symptom prevalence was not different between patients with and without hyperprolactinemia. Conclusion: This study showed that prevalence of hyperprolactinemia in subclinical hypothyroidism is notable and this disorder is more common in female subclinical hypothyroidism than the men.
Hyperprolactinemia, Subclinical hypothyroidism, Clinical symptom
229
233
http://caspjim.com/browse.php?a_code=A-10-62-48&slc_lang=en&sid=1
2014/01/142014/01/142014/01/142014/01/142014/01/142014/01/14
1392/10/24
2014/01/142014/01/142014/01/142014/01/142014/01/142014/01/14
1392/10/24
Adele
Bahar
003194753284600411
003194753284600411
Yes
Ozra
Akha
003194753284600412
003194753284600412
No
Zahra
Kashi
003194753284600413
003194753284600413
No
Zakiie
Vesgari
003194753284600414
003194753284600414
No
en
A periodontal health assessment of hospitalized patients with myocardial infarction
Background: Recent researches have known long term infections such as periodontal disease to be related with the process of atherosclerosis. Periodontitis causes peripheral inflammation and immune cell stimulation which leads to an increase in C - reactive protein (CRP) and IgA Ab and there is a definite relation between cardiovascular disease, CRP increase and Periodontitis. The aim of this study was to evaluate the periodontal health status of patients with myocardial infarction who were hospitalized in Babol and Sari Hospitals. Methods: This descriptive study was done on 95 men and women age ranging from 40 to 70 years old hospitalized due to myocardial infarction diagnosis in Babol and Sari Hospitals. Periodontal health, of patients evaluated via Cowell Bleeding Index, Green and vermillion Debri Index, Tooth Mobility, Clinical attachment Level on Ramfjord teeth. Data were analyzed with SPSS and Kruskal-Wallis test and Mann-whitney test. Results: Considered indexes were evaluated in 81men and 14 women studied which showed no significant difference among them in the average BI (p=0.52), average tooth mobility (p=0.117) and average CAL index (p=0.745). The only significant difference between men and women was found in average DI index (p=0.08). There was a significant difference between average CAL in Ramfjord teeth of upper and lower jaw (p=0.002). Conclusion: According to high prevalence of periodontitis in our study, periodontitis may be a risk factor of cardiovascular disease, it should be pointed out that here is the cardiologists' emphasis on their patients referring to the dentists.
Periodontitis, Myocardial Infarction, Clinical Attachment Level, Bleeding Index, Debri Index
234
239
http://caspjim.com/browse.php?a_code=A-10-62-49&slc_lang=en&sid=1
2014/01/142014/01/142014/01/142014/01/142014/01/142014/01/142014/01/14
1392/10/24
2014/01/142014/01/142014/01/142014/01/142014/01/142014/01/142014/01/14
1392/10/24
Babak
Amoian
003194753284600415
003194753284600415
Yes
Avideh
Maboudi
003194753284600416
003194753284600416
No
Vahid
Abbasi
003194753284600417
003194753284600417
No
en
Prevalence burn injuries and risk factors in persons older the 15 years in Urmia burn center in Iran
Background: Burn injuries in many respects is the most tragic that a person may experience. The purpose of this study was to know the burn casualties prevalence in people over 15 years old to identify the risk and predisposing factors in the province of west Azarbaijan of Iran. Methods: This cross-sectional study was performed from March 2008 to March 2010. The demographic and epidemiologic information about burn and its complications were extracted from the data banks and records. Data were collected and analyzed. Results:Four hundred twenty eight patients (44.9% female and 56.1% male) were studied. Most of the admissions were in 16 to 25 years age bracket. Burning with fire accounted (39.2%) of admission in males and (53.2%) in females which was the most common cause of burning. Percentage patients who had more than 40% body surface area (BSA) burned was 42.0% in males, and 30.1% in females. Patients with >40% BSA burn had a mortality of 73.8%. The mean body surface area burned was 33.8% in males and 25.2% in females. The mean duration of hospitalization was 6.19 days. Conclusion: The results of this study show that the prevalence of burn injuries is relatively high with high mortality rate in those with BSA> 40%. The commonest cause of burn was fire.
Burn injuries, Prevalence, Risk Factors
240
244
http://caspjim.com/browse.php?a_code=A-10-62-50&slc_lang=en&sid=1
2014/01/142014/01/142014/01/142014/01/142014/01/142014/01/142014/01/142014/01/14
1392/10/24
2014/01/142014/01/142014/01/142014/01/142014/01/142014/01/142014/01/142014/01/14
1392/10/24
Nader
Aghakhani
003194753284600418
003194753284600418
Yes
Hamid
Sharif Nia
003194753284600419
003194753284600419
No
Mohammad Ali
Soleimani
003194753284600420
003194753284600420
No
Nasim
Bahrami
003194753284600421
003194753284600421
No
Narges
Rahbar
003194753284600422
003194753284600422
No
Yadegar
Fattahi
003194753284600423
003194753284600423
No
Zahra
Beheshti
003194753284600424
003194753284600424
No
en
Pelger-Huet anomaly, Muscular atrophia, Optic nerve atrophia
Severe generalized muscular atrophia, nerve optic atrophia, ear problem and disability with Pelger-Huet anomaly
Background: The Pelger-Huet anomaly dominantly is a rare and benign inherited defect of terminal neutrophil differentiation. Although neutrophil migration may be minimally impaired, granulocytes function is otherwise normal association abnormalities such as ocular, musculoskeletal are reported very rare. Case: An eight year-old boy with good consciousness but severe muscular atrophia and difficulty in respiration was admitted in Amirkola Hospital at Babol University of Medical Sciences Babol, Iran. The patient was febrile at presentation. The chest x-ray was normal and other causes of respiratory problem were ruled out. The patient and his mother have 30% to 40% band and Pelger-Huet cells in peripheral blood smear. He gradually has gotten hearing loss and decreased visual acuity for three years. He has optic nerve atrophia. Conclusion: The patient is an unusual type of Pelger-Huet anomaly with multiple organ dysfunctions probably due to simultaneous muscular degenerative disease.
245
248
http://caspjim.com/browse.php?a_code=A-10-62-51&slc_lang=en&sid=1
2014/01/142014/01/142014/01/142014/01/142014/01/142014/01/142014/01/142014/01/142014/01/14
1392/10/24
2014/01/142014/01/142014/01/142014/01/142014/01/142014/01/142014/01/142014/01/142014/01/14
1392/10/24
Hassan
Mahmoodi Nesheli
003194753284600425
003194753284600425
Yes
Naimeh
Nakhjavani
003194753284600426
003194753284600426
No
Tahere
Galini Moghaddam
003194753284600427
003194753284600427
No