Caspian Journal of Internal Medicine

en The correlation between survival with clinical and pathological features of renal cancer patients after surgical intervention Nephrology Nephrology Original Article Original Article Background: Renal cell carcinoma (RCC) is a prevalent malignancy with a steadily increasing incidence. This study examined the association between clinical and pathological factors and RCC patient survival outcomes. Methods: This cross-sectional study enrolled patients diagnosed with malignant renal tumors who underwent surgical resection at Urmia Imam Khomeini Hospital between April 2017 and March 2022. Eligible patients were identified through a review of medical records and recruited using a convenience sampling method. Demographic, clinical, and pathological data were collected for each patient.  Results: Of the 171 patients, 104 were male and 67 were female with a mean age of 57.9 years (SD ±14.5). The one-, three, and five-year overall survival rates were 84.7%, 72.4%, and 70.5%, respectively. Univariate regression analysis revealed that five-year mortality following surgical intervention was strongly associated with moderate-to-severe anemia (HR 15.661, 95% CI 6.880-35.651, p < 0.001), elevated ESR (>50; HR 14.172, 95% CI 5.370-37.404, p < 0.001), presence of necrosis (HR 13.216, 95% CI 5.213-33.509, p < 0.001), and lymphovascular invasion (HR 7.988, 95% CI 4.184-15.251, p < 0.001). Multivariate regression analysis identified moderate-to-severe anemia, lymphovascular invasion, and large tumor size as strong predictors of five-year mortality. Conversely, the absence of anemia, lymphovascular invasion, and smaller tumor size (<6 cm) were associated with a lower mortality risk and improved survival. Overweight and obese patients exhibited a lower risk of mortality. Conclusion: These findings highlight the importance of considering clinical and pathological features in the management and prognosis of RCC patients.   Survival analysis, Nephrectomy, Renal cell carcinoma, clinical and pathological features 15 0 http://caspjim.com/browse.php?a_code=A-10-3619-1&slc_lang=en&sid=1 Mohammad Sadri drsadrihkc@gmail.com 100319475328460056469 100319475328460056469 Yes Department of Urology, School of Medicine, Urmia University of Medical Sciences, Urmia, Iran Sima Masudi masudi.s@umsu.ac.ir 100319475328460056470 100319475328460056470 No Department of Epidemiology, School of Medicine, Urmia University of Medical Sciences, Urmia, Iran Saman Farshid samanf63@gmail.com 100319475328460056471 100319475328460056471 No Department of Urology, School of Medicine, Urmia University of Medical Sciences, Urmia, Iran MohammadMehdi Nemati Oskuii nemati.m@gmail.com 100319475328460056472 0009-0004-2184-324X No Department of Urology, School of Medicine, Urmia University of Medical Sciences, Urmia, Iran