en Endocrinology Endocrinology Original Article Original Article <p><span style="font-size:14px;"><span style="font-family:Times New Roman;"><span style="line-height:150%"><span style="unicode-bidi:embed"><span sans-serif=""><span style="color:#0033ff;"><em><b><span style="line-height:150%"><span new="" roman="" times="">Background:</span></span></b></em></span><span style="line-height:150%"><span new="" roman="" times=""> Diabetes is a common metabolic disorder and one of its comorbidities is osteoporosis. In previous studies, the effect of lean mass and fat mass on bone has been investigated separately. Therefore, the aim of this study is to investigate the relationship between body composition with bone mineral density (BMD) and fractures in diabetic elderly.</span></span></span></span></span><br> <span style="line-height:150%"><span style="unicode-bidi:embed"><span sans-serif=""><span style="color:#0033ff;"><em><b><span style="line-height:150%"><span new="" roman="" times="">Methods</span></span></b></em></span><span style="line-height:150%"><span new="" roman="" times=""><span style="color:#0033ff;"><em>:</em></span> This population based cross-sectional study is part of the second phase of the Amirkola Health and Ageing Cohort Project (AHAP). Diabetes was diagnosed by fasting blood glucose level twice greater than or equal to 126 mg/dl. BMD and body composition were measured by Hologic Horizon-WI densitometer. History of fracture was obtained by asking the elderly individual. Then data were analyzed using statistical tests and ROC curve.</span></span></span></span></span><br> <span style="line-height:150%"><span style="unicode-bidi:embed"><span sans-serif=""><span style="color:#0033ff;"><em><b><span style="line-height:150%"><span new="" roman="" times="">Results:</span></span></b></em></span><span style="line-height:150%"><span new="" roman="" times=""><span style="color:#0033ff;"><em> </em></span>Out of 469 elderly diabetics, 270 (57.57%) were women. The mean age was 68.70 &plusmn; 6.18. Older people with osteopenia, osteoporosis and fracture had lower visceral fat mass (VFM), lean mass (LM) and waist circumference (WC) than normal people. The mean BMD in elderly with less than 10 years of diabetes history was greater and the percentage of fractures in elderly individuals with more than 10 years of diabetes was higher. In Roc analysis, the highest area under the curve was related to LM 78% (0.78 &plusmn; 0.02), WC 67% (0.67 &plusmn; 0.03) and VFM 62% (0.62 &plusmn; 0.03) for estimation of osteoporosis.</span></span></span></span></span><br> <span style="line-height:150%"><span style="unicode-bidi:embed"><span sans-serif=""><em><span style="color:#0033ff;"><b><span style="line-height:150%"><span new="" roman="" times="">Conclusions</span></span></b></span></em><span style="line-height:150%"><span new="" roman="" times=""><em><span style="color:#0033ff;">:</span></em> In this study, LM, WC and VFM had the greatest effect on BMD and fracture in elderly diabetic. </span></span></span></span></span><br> &nbsp;</span></span></p> Body composition, Lean mass, Bone mineral density, Type 2 diabetes mellitus, Elderly 8 0 http://caspjim.com/browse.php?a_code=A-10-403-5&slc_lang=en&sid=1 Seyed Amirhossein Hosseini hosseini.amir150@gmail.com 100319475328460056422 100319475328460056422 No Social Determinants of Health Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran Neda Meftah nedameftah@yahoo.com 100319475328460056423 100319475328460056423 No Clinical Research Development Center, Ayatollah Rohani Hospital, Babol University of Medical Sciences, Babol, Iran Mansor Babaei babaeim47@yahoo.com 100319475328460056424 100319475328460056424 No Social Determinants of Health Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran Ali Bijani alibijani@yahoo.com 100319475328460056425 100319475328460056425 No Social Determinants of Health Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran Reza Ghadimi rezaghadimi@yahoo.com 100319475328460056426 100319475328460056426 No Social Determinants of Health Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran Hajighorban Noreddini nooreddini@gmail.com 100319475328460056427 100319475328460056427 No Department of Radiology, School of Medicine, Babol University of Medical Sciences. Reza Hosseini hosseinirezaseyed@gmail.com 100319475328460056428 100319475328460056428 Yes Social Determinants of Health Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran