en Infectious Diseases Infectious Diseases Original Article Original Article <span style="font-size:14px;"><span style="font-family:Times New Roman;"><span style="line-height:14.3pt"><b><i><span style="color:blue">Background</span></i></b><i><span style="color:blue">:</span></i> Omicron was identified as one of the worrisome strains of corona virus<span style="color:red">.</span> Renal transplant recipients (RTRs) are classified as high-risk groups due to <span style="color:black">immunosuppressed conditions. Thus, this study was conducted with the aim of comparing these patients infected with the Omicron variant with the general population infected with this variant compare.</span></span><br> <span style="line-height:14.3pt"><b><i><span style="color:blue">Methods:</span></i></b> 62 RTRs infected with the Omicron strain and 60 patients with non-RTRs who were hospitalized from 2021 to 2022 at the peak of Omicron in Tehran, Shiraz and Babol, Iran were included in the study. The two groups were compared regarding clinical findings, laboratory results, pulmonary manifestations on high-resolution computed tomography (HRCT), and adverse effects.</span><br> <span style="line-height:14.3pt"><b><i><span style="color:blue">Results:</span></i></b> In both groups the most common respiratory symptoms were similar. The ground glass opacity was the most frequent finding on CT scan and was seen in 86 cases (70.5%). There was a reduced absolute lymphocyte count (ALC) and platelet count (85.4% and 41.9%, respectively) in RTRs and the rise of creatinine levels&nbsp; was more in RTRs than those in non-RTRs (79% versus 31.6%). the disease severity (16.1% versus 5%, P = 0.008) and adverse outcomes, such as mechanical ventilation (MV) (12.9% versus 0%, P = 0.004), and the mortality rate was significantly higher in RTRs than the general population.</span><br> <span style="line-height:14.3pt"><b><i><span style="color:blue">Conclusion</span></i></b><i><span style="color:blue">:</span></i> <span style="color:black">There was no significant difference in clinical symptoms between two groups except diarrhea</span>. MV, ICU admission and mortality were significantly higher in RTRs under prolonged immunosuppression.</span></span></span><br> &nbsp; Omicron, Renal Transplant recipients, Immunosuppression 642 652 http://caspjim.com/browse.php?a_code=A-10-1908-3&slc_lang=en&sid=1 Roghayeh Akbari rohanresearch88@gmail.com 100319475328460057893 100319475328460057893 No Infectious Diseases and Tropical Medicine Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran Sara Abolghasemi abolghasemi@gmail.com 100319475328460057894 100319475328460057894 No Infectious Diseases and Tropical Medicine Research Center, Shahid Beheshti University of Medical Science, Tehran, Iran Mojtaba Shafiekhani m.shafiekhani@gmail.com 100319475328460057895 100319475328460057895 No Shiraz Transplant Center, Abu-Ali Sina Hospital, Shiraz University of Medical Sciences, Shiraz, Iran Masoumeh Asgharpour masi9932002@yahoo.com 100319475328460057896 100319475328460057896 No Clinical Research Development Unit of Rouhani Hospital, Babol University of Medical Sciences, Babol, Iran Zahra Zare zahrazare368@yahoo.com 100319475328460057897 100319475328460057897 No Shiraz Transplant Center, Abu-Ali Sina Hospital, Shiraz University of Medical Sciences, Shiraz, Iran Hamed Nikoupour nikpour.h@gmail.com 100319475328460057898 100319475328460057898 No Shiraz Transplant Center, Abu-Ali Sina Hospital, Shiraz University of Medical Sciences, Shiraz, Iran Jamshid Roozbeh roozbeh@gmail.com 100319475328460057899 100319475328460057899 No Shiraz Transplant Center, Abu-Ali Sina Hospital, Shiraz University of Medical Sciences, Shiraz, Iran Elmira Mahmoudi Chalmiani Mahmoudi.e@gmail.com 100319475328460057900 100319475328460057900 No Infectious Diseases and Tropical Medicine Research Center, Shahid Beheshti University of Medical Science, Tehran, Iran. Farshid Oliaie ol_1964@yahoo.com 100319475328460057901 100319475328460057901 No Infectious Diseases and Tropical Medicine Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran. Mana Baziboroun manabaziboron@gmail.com 100319475328460057902 100319475328460057902 Yes Infectious Disease and Tropical Medicine Research Center, Shahid Beheshti University of Medical Science, Tehran, Iran. es and Tropical Medicine Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran. Shiva Nezami shvanezami1@gmail.com 100319475328460057903 100319475328460057903 No Infectious Disease and Tropical Medicine Research Center, Shahid Beheshti University of Medical Science, Tehran, Iran.