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:: Volume 14, Issue 3 (Summer 2023) ::
Caspian J Intern Med 2023, 14(3): 443-448 Back to browse issues page
Hematologic inflammatory indexes as a prognostic factor in endometrial cancer grading and staging
Mahdiss Mohamadianamiri , Majid Aklamli , Farzaneh Alemohammad
Student Research Committee, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran , farzaneh.almhd@gmail.com
Abstract:   (1058 Views)
Background: Endometrial cancer is one the most popular types of cancer in women in the world, also a common type of cancer among Iranian females. Neutrophils to lymphocytes (NLR) and platelet to lymphocyte (PLR) ratios are two practical and available indicators in endometrial cancer. We examined their correlation in these patients and determined that they could be used as a prognostic factor in grading and staging this cancer. This study takes a practical approach and recommends a screening strategy for asymptomatic women diagnosed with cancer in its early stages.
Methods: Endometrial cancer patients were included in this cross-sectional study based on histological findings. NLR is known as the proportion of neutrophils to absolute lymphocytes, while PLR is known as the proportion of platelets to lymphocytes. The NLR and PLR were evaluated and their relationship to the grade and stage of cancer.
Results: PLR and NLR values were calculated, and the mean values were 4.917±5.870 and 16.019±18.963, respectively. NLR and PLR were more significant in group 2 patients.  Additionally, a strong and    statistically significant relationship existed between these two methods (p<0.001). For the NL and PL methods, the optimal cutting point was 3.66 and 13.26, respectively. The NL method had a specificity of 0.906 and a sensitivity of 0.564. The PL and NL zones had values of 0.697 and 0.725, respectively.  Although there is no remarkable difference among these areas, the AUC of PL power is slightly better than the NL method. It demonstrates that they are capable of increasing detection power by more than 50%.
Conclusion: This study concluded that PLR and NLR were identified as independent prognostic items associated with the stage and grade of endometrial cancer.
Keywords: Endometrial Cancer, Inflammation, Neoplasm Grading, Prognostic Factor
Full-Text [PDF 217 kb]   (501 Downloads)    
Type of Study: Original Article | Subject: Hematology
Received: 2022/01/7 | Accepted: 2022/03/13 | Published: 2023/05/30
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Mohamadianamiri M, Aklamli M, Alemohammad F. Hematologic inflammatory indexes as a prognostic factor in endometrial cancer grading and staging. Caspian J Intern Med 2023; 14 (3) :443-448
URL: http://caspjim.com/article-1-3307-en.html

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Volume 14, Issue 3 (Summer 2023) Back to browse issues page
Caspian Journal of Internal Medicine
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